Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana
One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chrom...
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my.um.eprints.254572020-08-25T08:40:36Z http://eprints.um.edu.my/25457/ Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana Omar, Hanita Fadaeinasab, Mehran Taha, Hairin Widyawaruyanti, Aty Nafiah, Mohd Azlan Rachmatiah, Tiah Q Science (General) QD Chemistry One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3–6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Taylor & Francis 2020 Article PeerReviewed Omar, Hanita and Fadaeinasab, Mehran and Taha, Hairin and Widyawaruyanti, Aty and Nafiah, Mohd Azlan and Rachmatiah, Tiah (2020) Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana. Journal of Asian Natural Products Research, 22 (1). pp. 52-60. ISSN 1028-6020 https://doi.org/10.1080/10286020.2018.1553958 doi:10.1080/10286020.2018.1553958 |
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Q Science (General) QD Chemistry Omar, Hanita Fadaeinasab, Mehran Taha, Hairin Widyawaruyanti, Aty Nafiah, Mohd Azlan Rachmatiah, Tiah Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
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One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3–6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. |
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Article |
author |
Omar, Hanita Fadaeinasab, Mehran Taha, Hairin Widyawaruyanti, Aty Nafiah, Mohd Azlan Rachmatiah, Tiah |
author_facet |
Omar, Hanita Fadaeinasab, Mehran Taha, Hairin Widyawaruyanti, Aty Nafiah, Mohd Azlan Rachmatiah, Tiah |
author_sort |
Omar, Hanita |
title |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
title_short |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
title_full |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
title_fullStr |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
title_full_unstemmed |
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana |
title_sort |
aporphine alkaloids with in vitro antiplasmodial activity from the leaves of phoebe tavoyana |
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Taylor & Francis |
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2020 |
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http://eprints.um.edu.my/25457/ https://doi.org/10.1080/10286020.2018.1553958 |
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