Inhibition of lysosomal vacuolar proton pump down-regulates cellular acidification and enhances E. coli bactofection efficiency
Endosomal escape is considered a crucial barrier that needs to be overcome by integrin-mediated E. coli for gene delivery into mammalian cells. Bafilomycin, a potent inhibitor of the H+ proton pump commonly employed to lower endosomal pH, was evaluated as part of the E. coli protocol during delivery...
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| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Academic Press Inc Elsevier Science
2021
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/26536/ |
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| Institution: | Universiti Malaya |