From NSAIDs to glucocorticoids and beyond
Our interest in inflammation and its treatment stems from ancient times. Hippocrates used willow bark to treat inflammation, and many centuries later, salicylic acid and its derivative aspirin's ability to inhibit cyclooxygenase enzymes was discovered. Glucocorticoids (GC) ushered in a new era...
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my.um.eprints.270302022-04-14T00:55:52Z http://eprints.um.edu.my/27030/ From NSAIDs to glucocorticoids and beyond Sinniah, Ajantha Yazid, Samia Flower, Rod J. QH426 Genetics Our interest in inflammation and its treatment stems from ancient times. Hippocrates used willow bark to treat inflammation, and many centuries later, salicylic acid and its derivative aspirin's ability to inhibit cyclooxygenase enzymes was discovered. Glucocorticoids (GC) ushered in a new era of treatment for both chronic and acute inflammatory disease, but their potentially dangerous side effects led the pharmaceutical industry to seek other, safer, synthetic GC drugs. The discovery of the GC-inducible endogenous anti-inflammatory protein annexin A1 (AnxA1) and other endogenous proresolving mediators has opened a new era of anti-inflammatory therapy. This review aims to recapitulate the last four decades of research on NSAIDs, GCs, and AnxA1 and their anti-inflammatory effects. MDPI 2021-12 Article PeerReviewed Sinniah, Ajantha and Yazid, Samia and Flower, Rod J. (2021) From NSAIDs to glucocorticoids and beyond. Cells, 10 (12). ISSN 2073-4409, DOI https://doi.org/10.3390/cells10123524 <https://doi.org/10.3390/cells10123524>. 10.3390/cells10123524 |
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QH426 Genetics Sinniah, Ajantha Yazid, Samia Flower, Rod J. From NSAIDs to glucocorticoids and beyond |
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Our interest in inflammation and its treatment stems from ancient times. Hippocrates used willow bark to treat inflammation, and many centuries later, salicylic acid and its derivative aspirin's ability to inhibit cyclooxygenase enzymes was discovered. Glucocorticoids (GC) ushered in a new era of treatment for both chronic and acute inflammatory disease, but their potentially dangerous side effects led the pharmaceutical industry to seek other, safer, synthetic GC drugs. The discovery of the GC-inducible endogenous anti-inflammatory protein annexin A1 (AnxA1) and other endogenous proresolving mediators has opened a new era of anti-inflammatory therapy. This review aims to recapitulate the last four decades of research on NSAIDs, GCs, and AnxA1 and their anti-inflammatory effects. |
| format |
Article |
| author |
Sinniah, Ajantha Yazid, Samia Flower, Rod J. |
| author_facet |
Sinniah, Ajantha Yazid, Samia Flower, Rod J. |
| author_sort |
Sinniah, Ajantha |
| title |
From NSAIDs to glucocorticoids and beyond |
| title_short |
From NSAIDs to glucocorticoids and beyond |
| title_full |
From NSAIDs to glucocorticoids and beyond |
| title_fullStr |
From NSAIDs to glucocorticoids and beyond |
| title_full_unstemmed |
From NSAIDs to glucocorticoids and beyond |
| title_sort |
from nsaids to glucocorticoids and beyond |
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MDPI |
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2021 |
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http://eprints.um.edu.my/27030/ |
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