Actions of three clostridial IgA proteases on distinct forms of immunoglobulin A molecules

• Main Authors: Hashim, Onn Haji, Hassan, H.
• Format: Article
• Published: 1991
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/280/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1384471/?tool=pubmed
• Institution: Universiti Malaya

Three bacterial species of Clostridium (septicum, tertium and sporogenes) were identified to produce extracellular proteases cleaving IgA to Fab and Fc fragments, as demonstrated by SDS-PAGE and immunoelectrophoretic procedures. These enzymes acted on monometric IgA1 paraproteins and normal serum Ig...