The Bisindole Alkaloids Angustilongines M and A from Alstonia penangiana Induce Mitochondrial Apoptosis and G0/G1 Cell Cycle Arrest in HT-29 Cells through Promotion of Tubulin Polymerization

The Bisindole Alkaloids Angustilongines M and A from Alstonia penangiana Induce Mitochondrial Apoptosis and G0/G1 Cell Cycle Arrest in HT-29 Cells through Promotion of Tubulin Polymerization

A new linearly fused macroline-sarpagine bisindole, angustilongine M (1), was isolated from the methanolic extract of Alstonia penangiana. The structure of the alkaloid was elucidated based on analysis of the spectroscopic data, and its biological activity was evaluated together with another previou...

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Bibliographic Details
Main Authors: Tan, Chun-Hoe, Yeap, Joanne Soon-Yee, Lim, Siew-Huah, Low, Yun-Yee, Sim, Kae-Shin, Kam, Toh-Seok
Format: Article
Published: American Chemical Society 2021
Subjects:
QK Botany
RM Therapeutics. Pharmacology
Online Access:http://eprints.um.edu.my/28515/
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Institution: Universiti Malaya

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http://eprints.um.edu.my/28515/

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