Development and evaluation of 1 `-acetoxychavicol acetate (ACA)-loaded nanostructured lipid carriers for prostate cancer therapy

• Main Authors: Subramaniam, Bavani, Arshad, Norhafiza M., Malagobadan, Sharan, Misran, Misni, Nyamathulla, Shaik, Mun, Kein Seong, Nagoor, Noor Hasima
• Format: Article
• Published: MDPI 2021
• Subjects: RM Therapeutics. Pharmacology; TA Engineering (General). Civil engineering (General)
• Online Access: http://eprints.um.edu.my/28614/
• Institution: Universiti Malaya

1 `-acetoxychavicol acetate (ACA) extracted from the rhizomes of Alpinia conchigera Griff (Zingiberaceae) has been shown to deregulate the NF- signaling pathway and induce apoptosis-mediated cell death in many cancer types. However, ACA is a hydrophobic ester, with poor solubility in an aqueous medi...