Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?

Nanomedicine has seen a significant rise in the development of new research tools and clinically functional devices. In this regard, significant advances and new commercial applications are expected in the pharmaceutical and orthopedic industries. For advanced orthopedic implant technologies, approp...

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Main Authors: Sarraf, Masoud, Nasiri-Tabrizi, Bahman, Yeong, Chai Hong, Hosseini, Hamid Reza Madaah, Saber-Samandari, Saeed, Basirun, Wan Jefrey, Tsuzuki, Takuya
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Published: Elsevier 2021
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Online Access:http://eprints.um.edu.my/28749/
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spelling my.um.eprints.287492022-08-22T01:45:03Z http://eprints.um.edu.my/28749/ Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future? Sarraf, Masoud Nasiri-Tabrizi, Bahman Yeong, Chai Hong Hosseini, Hamid Reza Madaah Saber-Samandari, Saeed Basirun, Wan Jefrey Tsuzuki, Takuya QD Chemistry R Medicine Medical technology T Technology (General) Nanomedicine has seen a significant rise in the development of new research tools and clinically functional devices. In this regard, significant advances and new commercial applications are expected in the pharmaceutical and orthopedic industries. For advanced orthopedic implant technologies, appropriate nanoscale surface modifications are highly effective strategies and are widely studied in the literature for improving implant performance. It is well-established that implants with nanotubular surfaces show a drastic improvement in new bone creation and gene expression compared to implants without nanotopography. Nevertheless, the scientific and clinical understanding of mixed oxide nanotubes (MONs) and their potential applications, especially in biomedical applications are still in the early stages of development. This review aims to establish a credible platform for the current and future roles of MONs in nanomedicine, particularly in advanced orthopedic implants. We first introduce the concept of MONs and then discuss the preparation strategies. This is followed by a review of the recent advancement of MONs in biomedical applications, including mineralization abilities, biocompatibility, antibacterial activity, cell culture, and animal testing, as well as clinical possibilities. To conclude, we propose that the combination of nanotubular surface modification with incorporating sensor allows clinicians to precisely record patient data as a critical contributor to evidence-based medicine. Elsevier 2021-02-01 Article PeerReviewed Sarraf, Masoud and Nasiri-Tabrizi, Bahman and Yeong, Chai Hong and Hosseini, Hamid Reza Madaah and Saber-Samandari, Saeed and Basirun, Wan Jefrey and Tsuzuki, Takuya (2021) Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future? Ceramics International, 47 (3). pp. 2917-2948. ISSN 0272-8842, DOI https://doi.org/10.1016/j.ceramint.2020.09.177 <https://doi.org/10.1016/j.ceramint.2020.09.177>. 10.1016/j.ceramint.2020.09.177
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
R Medicine
Medical technology
T Technology (General)
spellingShingle QD Chemistry
R Medicine
Medical technology
T Technology (General)
Sarraf, Masoud
Nasiri-Tabrizi, Bahman
Yeong, Chai Hong
Hosseini, Hamid Reza Madaah
Saber-Samandari, Saeed
Basirun, Wan Jefrey
Tsuzuki, Takuya
Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?
description Nanomedicine has seen a significant rise in the development of new research tools and clinically functional devices. In this regard, significant advances and new commercial applications are expected in the pharmaceutical and orthopedic industries. For advanced orthopedic implant technologies, appropriate nanoscale surface modifications are highly effective strategies and are widely studied in the literature for improving implant performance. It is well-established that implants with nanotubular surfaces show a drastic improvement in new bone creation and gene expression compared to implants without nanotopography. Nevertheless, the scientific and clinical understanding of mixed oxide nanotubes (MONs) and their potential applications, especially in biomedical applications are still in the early stages of development. This review aims to establish a credible platform for the current and future roles of MONs in nanomedicine, particularly in advanced orthopedic implants. We first introduce the concept of MONs and then discuss the preparation strategies. This is followed by a review of the recent advancement of MONs in biomedical applications, including mineralization abilities, biocompatibility, antibacterial activity, cell culture, and animal testing, as well as clinical possibilities. To conclude, we propose that the combination of nanotubular surface modification with incorporating sensor allows clinicians to precisely record patient data as a critical contributor to evidence-based medicine.
format Article
author Sarraf, Masoud
Nasiri-Tabrizi, Bahman
Yeong, Chai Hong
Hosseini, Hamid Reza Madaah
Saber-Samandari, Saeed
Basirun, Wan Jefrey
Tsuzuki, Takuya
author_facet Sarraf, Masoud
Nasiri-Tabrizi, Bahman
Yeong, Chai Hong
Hosseini, Hamid Reza Madaah
Saber-Samandari, Saeed
Basirun, Wan Jefrey
Tsuzuki, Takuya
author_sort Sarraf, Masoud
title Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?
title_short Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?
title_full Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?
title_fullStr Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?
title_full_unstemmed Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?
title_sort mixed oxide nanotubes in nanomedicine: a dead-end or a bridge to the future?
publisher Elsevier
publishDate 2021
url http://eprints.um.edu.my/28749/
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