Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children

• Main Authors: Sies, Nur Syazwin, Zaini, Azriyanti Anuar, de Bruyne, Jessie Anne, Jalaludin, Muhammad Yazid, Nathan, Anna Marie, Han, Ng Yit, Thavagnanam, Surendran
• Format: Article
• Published: Nature Research 2021
• Subjects: RJ Pediatrics
• Online Access: http://eprints.um.edu.my/28844/
• Institution: Universiti Malaya

Repetitive hypoxia seen in obstructive sleep apnoea syndrome (OSAS) may affect bone metabolism increasing the risk for secondary osteoporosis. This study investigates the association between OSAS in children and secondary osteoporosis. This cross-sectional study included 150 children aged 10-17 years: 86 with OSAS and 64 with no OSAS. OSAS was confirmed by polysomnography. Quantitative ultrasound (QUS) of calcaneum measuring speed of sound (SoS) and broadband ultrasound attenuation (BUA) were collected. Other parameters collected including bone profile, vitamin D levels, physical activity scoring and dietary calcium intake. Majority were male and Malay ethnicity. OSAS children were mostly obese (84%) and 57% had moderate to severe OSAS. Most had lower physical activities scores. Mean (SD) phosphate and Alkaline phosphatase were lower in OSA children compared to controls: PO4, p=0.039 and ALP, p<0.001. Using both single and multivariate analysis, children with OSAS had a lower mean SoS value, p<0.001 and p=0.004 respectively after adjusting for age, BMI and bone profile. Children with OSAS had lower SoS suggesting risk for secondary osteoporosis. QUS calcaneus is a non-invasive, feasible tool and can be used to screen risk of osteoporosis in children. Further bone mineral density assessment is needed in these groups of children to confirm diagnosis of osteoporosis.