Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents
Functionalized magnetite nanoparticles (Fe3O4) were prepared using the coprecipitation method followed by functionalization with a multipotent antioxidant (MPAO). The MPAO was synthesized and analyzed using FTIR and NMR techniques. In this study, the functionalized nanoparticles (IONP@AO) were produ...
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my.um.eprints.334352023-12-01T07:13:12Z http://eprints.um.edu.my/33435/ Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents Shah, Syed Tawab Chowdhury, Zaira Zaman Johan, Mohd Rafie Badruddin, Irfan Anjum Khaleed, H. M. T. Kamangar, Sarfaraz Alrobei, Hussein QD Chemistry QH301 Biology Functionalized magnetite nanoparticles (Fe3O4) were prepared using the coprecipitation method followed by functionalization with a multipotent antioxidant (MPAO). The MPAO was synthesized and analyzed using FTIR and NMR techniques. In this study, the functionalized nanoparticles (IONP@AO) were produced and evaluated using the FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX techniques. The average determined particle size of IONP@AO was 10 nanometers. In addition, it demonstrated superparamagnetic properties. The magnitude of saturation magnetization value attained was 45 emu g(-1). Virtual screenings of the MPAO's potential bioactivities and safety profile were performed using PASS analysis and ADMET studies before the synthesis step. For the DPPH test, IONP@AO was found to have a four-fold greater ability to scavenge free radicals than unfunctional IONP. The antimicrobial properties of IONP@AO were also demonstrated against a variety of bacteria and fungi. The interaction of developed nanoantioxiants with biomolecules makes it a broad-spectrum candidate in biomedicine and nanomedicine. MDPI 2022-02 Article PeerReviewed Shah, Syed Tawab and Chowdhury, Zaira Zaman and Johan, Mohd Rafie and Badruddin, Irfan Anjum and Khaleed, H. M. T. and Kamangar, Sarfaraz and Alrobei, Hussein (2022) Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents. Molecules, 27 (3). ISSN 1420-3049, DOI https://doi.org/10.3390/molecules27030789 <https://doi.org/10.3390/molecules27030789>. 10.3390/molecules27030789 |
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QD Chemistry QH301 Biology Shah, Syed Tawab Chowdhury, Zaira Zaman Johan, Mohd Rafie Badruddin, Irfan Anjum Khaleed, H. M. T. Kamangar, Sarfaraz Alrobei, Hussein Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents |
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Functionalized magnetite nanoparticles (Fe3O4) were prepared using the coprecipitation method followed by functionalization with a multipotent antioxidant (MPAO). The MPAO was synthesized and analyzed using FTIR and NMR techniques. In this study, the functionalized nanoparticles (IONP@AO) were produced and evaluated using the FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX techniques. The average determined particle size of IONP@AO was 10 nanometers. In addition, it demonstrated superparamagnetic properties. The magnitude of saturation magnetization value attained was 45 emu g(-1). Virtual screenings of the MPAO's potential bioactivities and safety profile were performed using PASS analysis and ADMET studies before the synthesis step. For the DPPH test, IONP@AO was found to have a four-fold greater ability to scavenge free radicals than unfunctional IONP. The antimicrobial properties of IONP@AO were also demonstrated against a variety of bacteria and fungi. The interaction of developed nanoantioxiants with biomolecules makes it a broad-spectrum candidate in biomedicine and nanomedicine. |
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Article |
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Shah, Syed Tawab Chowdhury, Zaira Zaman Johan, Mohd Rafie Badruddin, Irfan Anjum Khaleed, H. M. T. Kamangar, Sarfaraz Alrobei, Hussein |
author_facet |
Shah, Syed Tawab Chowdhury, Zaira Zaman Johan, Mohd Rafie Badruddin, Irfan Anjum Khaleed, H. M. T. Kamangar, Sarfaraz Alrobei, Hussein |
author_sort |
Shah, Syed Tawab |
title |
Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents |
title_short |
Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents |
title_full |
Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents |
title_fullStr |
Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents |
title_full_unstemmed |
Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents |
title_sort |
surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents |
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MDPI |
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2022 |
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http://eprints.um.edu.my/33435/ |
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