Chitosan-coated-PLGA nanoparticles enhance the antitumor and antimigration activity of stattic : A STAT3 dimerization blocker

• Main Authors: Fong, Stephanie Sally, Foo, Yiing Yee, Saw, Wen Shang, Leo, Bey Fen, Teo, Yin Yin, Chung, Ivy, Goh, Boon Tong, Misran, Misni, Imae, Toyoko, Chang, Chia-Ching, Chung, Lip Yong, Kiew, Lik Voon
• Format: Article
• Published: Dove Medical Press 2022
• Subjects: Q Science (General); R Medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer); RD Surgery
• Online Access: http://eprints.um.edu.my/33542/
• Institution: Universiti Malaya

The use of nanocarriers to improve the delivery and efficacy of antimetastatic agents is less explored when compared to cytotoxic agents. This study reports the entrapment of an antimetastatic Signal Transducer and Activator of Transcription 3 (STAT3) dimeriza-tion blocker, Stattic (S) into a chitos...