APOE, TOMM40, and sex interactions on neural network connectivity

• Main Authors: Li, Tianqi, Pappas, Colleen, Le, Scott T., Wang, Qian, Klinedinst, Brandon S., Larsen, Brittany A., Pollpeter, Amy, Lee, Ling Yi, Lutz, Mike W., Gottschalk, William K., Swerdlow, Russell H., Nho, Kwangsik, Willette, Auriel A.
• Format: Article
• Published: Elsevier Science Inc 2022
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: http://eprints.um.edu.my/33711/
• Institution: Universiti Malaya

The Apolipoprotein E epsilon 4 (APOE epsilon 4) haplotype is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). The Translocase of Outer Mitochondrial Membrane-40 (TOMM40) gene maintains cellular bioenergetics, which is disrupted in AD. TOMM40 rs2075650 ('650) G ver...