Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines

• Main Authors: Morais, Christudas, Rajandram, Retnagowri, Blakeney, Jade S., Iyer, Abishek, Suen, Jacky Y., Johnson, David W., Gobe, Glenda C., Fairlie, David P., Vesey, David A.
• Format: Article
• Published: PUBLIC LIBRARY SCIENCE
• Online Access: http://eprints.um.edu.my/34231/
• Institution: Universiti Malaya

Expression of the protease sensing receptor, protease activated receptor-2 (PAR2), is elevated in a variety of cancers and has been promoted as a potential therapeutic target. With the development of potent antagonists for this receptor, we hypothesised that they could be used to treat renal cell ca...