Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NF kappa B to promote axonal regeneration and remyelination

• Main Authors: Yadav, Anjali, Huang, Tzu-Chieh, Chen, Szu-Han, Ramasamy, Thamil Selvee, Hsueh, Yuan-Yu, Lin, Shau-Ping, Lu, Fu-, Liu, Ya-Hsin, Wu, Chia-Ching
• Format: Article
• Published: BMC 2021
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/34294/
• Institution: Universiti Malaya

Epigenetic regulation by histone deacetylases (HDACs) in Schwann cells (SCs) after injury facilitates them to undergo de- and redifferentiation processes necessary to support various stages of nerve repair. Although de-differentiation activates the synthesis and secretion of inflammatory cytokines b...