Triptolide inhibits epithelial-mesenchymal transition phenotype through the p70S6k/GSK3/beta-catenin signaling pathway in taxol-resistant human lung adenocarcinoma

• Main Authors: Tian, Yu, Li, Peiwei, Xiao, Zhaohua, Zhou, Jie, Xue, Xia, Jiang, Ning, Peng, Chuanliang, Wu, Licun, Tian, Hui, Popper, Helmut, Poh, Mau-Ern, Marcucci, Fabrizio, Zhang, Chengke, Zhao, Xiaogang
• Format: Article
• Published: Ame Publ Co 2021
• Subjects: R Medicine; RC Internal medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/34573/
• Institution: Universiti Malaya

Chemotherapy is one of the primary treatments for both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), however, chemoresistance develops over time and is a bottleneck to effective chemotherapy worldwide. Therefore, the development of new potent therapeutic agents to overcome ch...