Epidemiological and ES cell-based functional evaluation of BRCA2 variants identified in families with breast cancer

• Main Authors: Sullivan, Teresa, Thirthagiri, Eswary, Chong, Chan-Eng, Stauffer, Stacey, Reid, Susan, Southon, Eileen, Hassan, Tiara, Ravichandran, Aravind, Wijaya, Eldarina, Lim, Joanna, Taib, Nur Aishah Mohd, Fadzli, Farhana, Yip, Cheng Har, Hartman, Mikael, Li, Jingmei, van Dam, Rob M., North, Susan L., Das, Ranabir, Easton, Douglas F., Biswas, Kajal, Teo, Soo-Hwang, Sharan, Shyam K., Investigators, SGBCC, Investigators, MYBRCA
• Format: Article
• Published: Wiley 2021
• Subjects: R Medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer); RD Surgery
• Online Access: http://eprints.um.edu.my/34662/
• Institution: Universiti Malaya

The discovery of high-risk breast cancer susceptibility genes, such as Breast cancer associated gene 1 (BRCA1) and Breast cancer associated gene 2 (BRCA2) has led to accurate identification of individuals for risk management and targeted therapy. The rapid decline in sequencing costs has tremendousl...