Genetic justification of severe COVID-19 using a rigorous algorithm

• Main Authors: Gavriilaki, Eleni, Asteris, Panagiotis G., Touloumenidou, Tasoula, Koravou, Evaggelia-Evdoxia, Koutra, Maria, Papayanni, Penelope Georgia, Karali, Vassiliki, Papalexandri, Apostolia, Varelas, Christos, Chatzopoulou, Fani, Chatzidimitriou, Maria, Chatzidimitriou, Dimitrios, Veleni, Anastasia, Grigoriadis, Savvas, Rapti, Evdoxia, Chloros, Diamantis, Kioumis, Ioannis, Kaimakamis, Evaggelos, Bitzani, Milly, Boumpas, Dimitrios, Tsantes, Argyris, Sotiropoulos, Damianos, Sakellari, Ioanna, Kalantzis, Ioannis G., Parastatidis, Stefanos T., Koopialipoor, Mohammadreza, Cavaleri, Liborio, Armaghani, Danial J., Papadopoulou, Anastasia, Brodsky, Robert Alan, Kokoris, Styliani, Anagnostopoulos, Achilles
• Format: Article
• Published: Academic Press 2021
• Subjects: R Medicine; RB Pathology
• Online Access: http://eprints.um.edu.my/34693/
• Institution: Universiti Malaya

Recent studies suggest excessive complement activation in severe coronavirus disease-19 (COVID-19). The latter shares common characteristics with complement-mediated thrombotic microangiopathy (TMA). We hypothesized that genetic susceptibility would be evident in patients with severe COVID-19 (simil...