Lupus susceptibility region containing CDKN1B rs34330 mechanistically influences expression and function of multiple target genes, also linked to proliferation and apoptosis

• Main Authors: Singh, Bhupinder, Maiti, Guru P., Zhou, Xujie, Fazel-Najafabadi, Mehdi, Bae, Sang-Cheol, Sun, Celi, Terao, Chikashi, Okada, Yukinori, Chua, Kek Heng, Kochi, Yuta, Guthridge, Joel M., Zhang, Hong, Weirauch, Matthew, James, Judith A., Harley, John B., Varshney, Gaurav K., Looger, Loren L., Nath, Swapan K.
• Format: Article
• Published: Wiley 2021
• Subjects: R Medicine; RL Dermatology
• Online Access: http://eprints.um.edu.my/35327/
• Institution: Universiti Malaya

In a recent genome-wide association study, a significant genetic association between rs34330 of CDKN1B and risk of systemic lupus erythematosus (SLE) in Han Chinese was identified. This study was undertaken to validate the reported association and elucidate the biochemical mechanisms underlying the...