The rotational effect of magnetic particles on cellular apoptosis based on four electromagnet feedback control system

• Main Authors: Lee, Jia Ji, Pua, Chang Hong, Misran, Misni, Lee, Poh Foong
• Format: Article
• Published: World Scientific 2021
• Subjects: QD Chemistry; TP Chemical technology
• Online Access: http://eprints.um.edu.my/35929/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110448521&doi=10.4015%2fS1016237221500459&partnerID=40&md5=1855a45d66caa52000123bd27c2779b7
• Institution: Universiti Malaya

Objectives: Magnetic drug targeting offers the latest popular alternative option to deliver magnetic drug carriers into targeting region body parts through manipulation of an external magnetic field. However, the effectiveness of using an electromagnetic field to manipulate and directing magnetic particles is yet to be established. Methods: In this paper, a homemade cost-effective electromagnet system was built for the purpose of studying the control and directing the magnetic drug carriers. The electromagnet system was built with four electromagnetic sources and tested the capability in directing the particles' movement in different geometry patterns. Besides that, the creation of the self-rotation of individual magnetic particle clusters was achieved by using fast switching between magnetic fields. This self-rotation allows the possibility of cell apoptosis study to carry out. The system was constructed with four electromagnets integrated with a feedback control system and built to manipulate a droplet of commercially available iron (II, III) oxide nanoparticles to steer the magnetic droplet along different arbitrary trajectories (square, circle, triangle, slanted line) in 2-dimensional. Results: A dynamic magnetic field of 25 Hz was induced for magnetic nanoparticles rotational effect to observe the cell apoptosis. A profound outcome shows that the declining cell viability of the cell lines by 40 and the morphology of shrinking cells after the exposure of the dynamic magnetic field. Conclusion: The outcome from the pilot study gives an idea on the laboratory setup serves as a fundamental model for studying the electromagnetic field strength in applying mechanical force to target and to rotate for apoptosis on cancer cell line study. © 2021 National Taiwan University.