Development of MicroRNAs as potential therapeutics against cancer

Development of MicroRNAs as potential therapeutics against cancer

MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpres...

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Main Authors: Abd-Aziz, Noraini, Kamaruzman, Nur Izyani, Poh, Chit Laa
Format: Article
Published: Hindawi Ltd 2020
Subjects:
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:http://eprints.um.edu.my/36543/
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Institution: Universiti Malaya
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spelling my.um.eprints.365432024-10-29T08:02:26Z http://eprints.um.edu.my/36543/ Development of MicroRNAs as potential therapeutics against cancer Abd-Aziz, Noraini Kamaruzman, Nur Izyani Poh, Chit Laa RC0254 Neoplasms. Tumors. Oncology (including Cancer) MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpression of oncogenic miRNAs (oncomiRs) or reduced expression of tumor suppressor miRNAs has been reported. In this review, we discuss the involvement of miRNAs in tumorigenesis, the role of synthetic miRNAs as either mimics or antagomirs to overcome cancer growth, miRNA delivery, and approaches to enhance their therapeutic potentials. Hindawi Ltd 2020-07 Article PeerReviewed Abd-Aziz, Noraini and Kamaruzman, Nur Izyani and Poh, Chit Laa (2020) Development of MicroRNAs as potential therapeutics against cancer. Journal of Oncology, 2020. ISSN 16878450, DOI https://doi.org/10.1155/2020/8029721 <https://doi.org/10.1155/2020/8029721>. 10.1155/2020/8029721
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Abd-Aziz, Noraini
Kamaruzman, Nur Izyani
Poh, Chit Laa
Development of MicroRNAs as potential therapeutics against cancer
description MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpression of oncogenic miRNAs (oncomiRs) or reduced expression of tumor suppressor miRNAs has been reported. In this review, we discuss the involvement of miRNAs in tumorigenesis, the role of synthetic miRNAs as either mimics or antagomirs to overcome cancer growth, miRNA delivery, and approaches to enhance their therapeutic potentials.
format Article
author Abd-Aziz, Noraini
Kamaruzman, Nur Izyani
Poh, Chit Laa
author_facet Abd-Aziz, Noraini
Kamaruzman, Nur Izyani
Poh, Chit Laa
author_sort Abd-Aziz, Noraini
title Development of MicroRNAs as potential therapeutics against cancer
title_short Development of MicroRNAs as potential therapeutics against cancer
title_full Development of MicroRNAs as potential therapeutics against cancer
title_fullStr Development of MicroRNAs as potential therapeutics against cancer
title_full_unstemmed Development of MicroRNAs as potential therapeutics against cancer
title_sort development of micrornas as potential therapeutics against cancer
publisher Hindawi Ltd
publishDate 2020
url http://eprints.um.edu.my/36543/
_version_ 1814933199356166144

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