Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort

Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of anti...

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Main Authors: Butt, Julia, Jenab, Mazda, Pawlita, Michael, Tjonneland, Anne, Kyro, Cecilie, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Dong, Catherine, Kaaks, Rudolf, Kuhn, Tilman, Boeing, Heiner, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Weiderpass, Elisabete, Borch, Kristin Benjaminsen, Quiros, Jose Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Santiuste, Carmen, Ardanaz, Eva, Van Guelpen, Bethany, Harlid, Sophia, Imaz, Liher, Perez-Cornago, Aurora, Gunter, Marc J., Zouiouich, Semi, Park, Jin Young, Riboli, Elio, Cross, Amanda J., Heath, Alicia K., Waterboer, Tim, Hughes, David J.
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Published: American Association for Cancer Research 2020
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Online Access:http://eprints.um.edu.my/36564/
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spelling my.um.eprints.365642024-07-17T03:32:20Z http://eprints.um.edu.my/36564/ Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort Butt, Julia Jenab, Mazda Pawlita, Michael Tjonneland, Anne Kyro, Cecilie Boutron-Ruault, Marie-Christine Carbonnel, Franck Dong, Catherine Kaaks, Rudolf Kuhn, Tilman Boeing, Heiner Schulze, Matthias B. Trichopoulou, Antonia Karakatsani, Anna La Vecchia, Carlo Palli, Domenico Agnoli, Claudia Tumino, Rosario Sacerdote, Carlotta Panico, Salvatore Bueno-de-Mesquita, Bas Vermeulen, Roel Gram, Inger T. Weiderpass, Elisabete Borch, Kristin Benjaminsen Quiros, Jose Ramon Agudo, Antonio Rodriguez-Barranco, Miguel Santiuste, Carmen Ardanaz, Eva Van Guelpen, Bethany Harlid, Sophia Imaz, Liher Perez-Cornago, Aurora Gunter, Marc J. Zouiouich, Semi Park, Jin Young Riboli, Elio Cross, Amanda J. Heath, Alicia K. Waterboer, Tim Hughes, David J. RC0254 Neoplasms. Tumors. Oncology (including Cancer) Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00-1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19-2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99-1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence. American Association for Cancer Research 2020-07 Article PeerReviewed Butt, Julia and Jenab, Mazda and Pawlita, Michael and Tjonneland, Anne and Kyro, Cecilie and Boutron-Ruault, Marie-Christine and Carbonnel, Franck and Dong, Catherine and Kaaks, Rudolf and Kuhn, Tilman and Boeing, Heiner and Schulze, Matthias B. and Trichopoulou, Antonia and Karakatsani, Anna and La Vecchia, Carlo and Palli, Domenico and Agnoli, Claudia and Tumino, Rosario and Sacerdote, Carlotta and Panico, Salvatore and Bueno-de-Mesquita, Bas and Vermeulen, Roel and Gram, Inger T. and Weiderpass, Elisabete and Borch, Kristin Benjaminsen and Quiros, Jose Ramon and Agudo, Antonio and Rodriguez-Barranco, Miguel and Santiuste, Carmen and Ardanaz, Eva and Van Guelpen, Bethany and Harlid, Sophia and Imaz, Liher and Perez-Cornago, Aurora and Gunter, Marc J. and Zouiouich, Semi and Park, Jin Young and Riboli, Elio and Cross, Amanda J. and Heath, Alicia K. and Waterboer, Tim and Hughes, David J. (2020) Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort. Cancer Epidemiology Biomarkers & Prevention, 29 (7). pp. 1475-1481. ISSN 1055-9965, DOI https://doi.org/10.1158/1055-9965.EPI-19-1545 <https://doi.org/10.1158/1055-9965.EPI-19-1545>. 10.1158/1055-9965.EPI-19-1545
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Butt, Julia
Jenab, Mazda
Pawlita, Michael
Tjonneland, Anne
Kyro, Cecilie
Boutron-Ruault, Marie-Christine
Carbonnel, Franck
Dong, Catherine
Kaaks, Rudolf
Kuhn, Tilman
Boeing, Heiner
Schulze, Matthias B.
Trichopoulou, Antonia
Karakatsani, Anna
La Vecchia, Carlo
Palli, Domenico
Agnoli, Claudia
Tumino, Rosario
Sacerdote, Carlotta
Panico, Salvatore
Bueno-de-Mesquita, Bas
Vermeulen, Roel
Gram, Inger T.
Weiderpass, Elisabete
Borch, Kristin Benjaminsen
Quiros, Jose Ramon
Agudo, Antonio
Rodriguez-Barranco, Miguel
Santiuste, Carmen
Ardanaz, Eva
Van Guelpen, Bethany
Harlid, Sophia
Imaz, Liher
Perez-Cornago, Aurora
Gunter, Marc J.
Zouiouich, Semi
Park, Jin Young
Riboli, Elio
Cross, Amanda J.
Heath, Alicia K.
Waterboer, Tim
Hughes, David J.
Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort
description Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00-1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19-2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99-1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence.
format Article
author Butt, Julia
Jenab, Mazda
Pawlita, Michael
Tjonneland, Anne
Kyro, Cecilie
Boutron-Ruault, Marie-Christine
Carbonnel, Franck
Dong, Catherine
Kaaks, Rudolf
Kuhn, Tilman
Boeing, Heiner
Schulze, Matthias B.
Trichopoulou, Antonia
Karakatsani, Anna
La Vecchia, Carlo
Palli, Domenico
Agnoli, Claudia
Tumino, Rosario
Sacerdote, Carlotta
Panico, Salvatore
Bueno-de-Mesquita, Bas
Vermeulen, Roel
Gram, Inger T.
Weiderpass, Elisabete
Borch, Kristin Benjaminsen
Quiros, Jose Ramon
Agudo, Antonio
Rodriguez-Barranco, Miguel
Santiuste, Carmen
Ardanaz, Eva
Van Guelpen, Bethany
Harlid, Sophia
Imaz, Liher
Perez-Cornago, Aurora
Gunter, Marc J.
Zouiouich, Semi
Park, Jin Young
Riboli, Elio
Cross, Amanda J.
Heath, Alicia K.
Waterboer, Tim
Hughes, David J.
author_facet Butt, Julia
Jenab, Mazda
Pawlita, Michael
Tjonneland, Anne
Kyro, Cecilie
Boutron-Ruault, Marie-Christine
Carbonnel, Franck
Dong, Catherine
Kaaks, Rudolf
Kuhn, Tilman
Boeing, Heiner
Schulze, Matthias B.
Trichopoulou, Antonia
Karakatsani, Anna
La Vecchia, Carlo
Palli, Domenico
Agnoli, Claudia
Tumino, Rosario
Sacerdote, Carlotta
Panico, Salvatore
Bueno-de-Mesquita, Bas
Vermeulen, Roel
Gram, Inger T.
Weiderpass, Elisabete
Borch, Kristin Benjaminsen
Quiros, Jose Ramon
Agudo, Antonio
Rodriguez-Barranco, Miguel
Santiuste, Carmen
Ardanaz, Eva
Van Guelpen, Bethany
Harlid, Sophia
Imaz, Liher
Perez-Cornago, Aurora
Gunter, Marc J.
Zouiouich, Semi
Park, Jin Young
Riboli, Elio
Cross, Amanda J.
Heath, Alicia K.
Waterboer, Tim
Hughes, David J.
author_sort Butt, Julia
title Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort
title_short Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort
title_full Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort
title_fullStr Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort
title_full_unstemmed Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort
title_sort antibody responses to helicobacter pylori and risk of developing colorectal cancer in a european cohort
publisher American Association for Cancer Research
publishDate 2020
url http://eprints.um.edu.my/36564/
_version_ 1805881187740155904