Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes

• Main Authors: Poh, R., Muniandy, S.
• Format: Article
• Language: English
• Published: Seameo Regional Tropical Medicine & Public Health 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/3662/1/4879_sept_2010.pdf; http://eprints.um.edu.my/3662/; http://www.tm.mahidol.ac.th/seameo/2010-41-5/24-4879.pdf
• Institution: Universiti Malaya

The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a reduction in activity towards paraoxon was associated with a significant increase in risk (p=0.023) for cardiovascular disease complications in diabetic patients. Multivariate analysis of two plasma measures of paraoxonase activity using paraoxon and diazoxon also showed reduced paraoxonase activity towards paraoxon was associated with a significant increase in risk (p=0.045) for cardiovascular disease complications in diabetic patients. These analyses showed that a reduced paraoxonase activity towards paraoxon was associated with ethnicity. Based on multivariate analysis, subjects of Malay ethnic origin have significantly higher than expected activity (p=0.008, compared to Indians), towards paraoxon than subjects of Chinese origin who in turn had higher than expected paraoxonase activity (p=0.028, compared to Indians) Indian subjects.