DNA methylation analysis of AKT1 promoter and HTR2A Exon-I of Malaysian schizophrenia multiplex families with lower cognitive performance

• Main Authors: Laere, Erna, Chow, Tze Jen, Tang, Pek Yee, Loh, Stew Yim, Yong, Hoi Sen, Kadir, Abdul, Bakar, Abu, Tee, Shiau Foon
• Format: Article
• Published: Penerbit Universiti Kebangsaan Malaysia 2020
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/36847/
• Institution: Universiti Malaya

Dysfunction of cognitive performance in schizophrenia has been associated with aberrant alteration of DNA methylation of several schizophrenia-risk genes. AKT1 and HTR2A are among the candidate genes for schizophrenia. Their expressions were found reduced in schizophrenia patients. Thus, we aimed to...