COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data
BackgroundManagement strategies of chronic obstructive pulmonary disease (COPD) need to be tailored to the forced expiratory volume in one second (FEV1), exacerbations, and patient-reported outcomes (PROs) of individual patients. In this study, we analyzed the association and correlation between the...
Saved in:
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Published: |
BMC
2023
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/38263/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universiti Malaya |
id |
my.um.eprints.38263 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.382632023-06-23T08:25:19Z http://eprints.um.edu.my/38263/ COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data Chai, Chee-Shee Ng, Diana-Leh-Ching Bt Mos, Sumastika Ibrahim, Muhammad Amin B. Tan, Seng-Beng Pang, Yong Kek Liam, Chong Kin R Medicine (General) BackgroundManagement strategies of chronic obstructive pulmonary disease (COPD) need to be tailored to the forced expiratory volume in one second (FEV1), exacerbations, and patient-reported outcomes (PROs) of individual patients. In this study, we analyzed the association and correlation between the FEV1, exacerbations, and PROs of patients with stable COPD.MethodsThis was a post-hoc analysis of pooled data from two cross-sectional studies that were previously conducted in Malaysia from 2017 to 2019, the results of which had been published separately. The parameters measured included post-bronchodilator FEV1 (PB-FEV1), exacerbations, and scores of modified Medical Research Council (mMRC), COPD Assessment Test (CAT), and St George's Respiratory Questionnaire for COPD (SGRQ-c). Descriptive, association, and correlation statistics were used.ResultsThree hundred seventy-four patients were included in the analysis. The PB-FEV1 predicted was < 30% in 85 (22.7%), 30-49% in 142 (38.0%), 50-79% in 111 (29.7%), and >= 80% in 36 (9.6%) patients. Patients with PB-FEV1 < 30% predicted had significantly more COPD exacerbations than those with PB-FEV1 30-49% predicted (p < 0.001), 50-79% predicted (p < 0.001), and >= 80% predicted (p = 0.002). The scores of mMRC, CAT, and SGRQ-c were not significantly higher in patients with more severe airflow limitation based on PB-FEV1 (p = 0.121-0.271). The PB-FEV1 predicted had significant weak negative correlations with exacerbations (r = - 0.182, p < 0.001), mMRC (r = - 0.121, p = 0.020), and SGRQ-c scores (r = - 0.114, p = 0.028). There was a moderate positive correlation between COPD exacerbations and scores of mMRC, CAT, and SGRQ-c (r = 0.407-0.482, all p < 0.001). There were significant strong positive correlations between mMRC score with CAT (r = 0.727) and SGRQ-c scores (r = 0.847), and CAT score with SGRQ-c score (r = 0.851) (all p < 0.001).ConclusionsIn COPD patients, different severity of airflow limitation was not associated with significant differences in the mMRC, CAT, and SGRQ-c scores. Exacerbations were significantly more frequent in patients with very severe airflow limitation only. The correlation between airflow limitation with exacerbations, mMRC, and SGRQ-c was weak. BMC 2023-04 Article PeerReviewed Chai, Chee-Shee and Ng, Diana-Leh-Ching and Bt Mos, Sumastika and Ibrahim, Muhammad Amin B. and Tan, Seng-Beng and Pang, Yong Kek and Liam, Chong Kin (2023) COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data. BMC Pulmonary Medicine, 23 (1). ISSN 1471-2466, DOI https://doi.org/10.1186/s12890-023-02436-1 <https://doi.org/10.1186/s12890-023-02436-1>. 10.1186/s12890-023-02436-1 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
R Medicine (General) |
spellingShingle |
R Medicine (General) Chai, Chee-Shee Ng, Diana-Leh-Ching Bt Mos, Sumastika Ibrahim, Muhammad Amin B. Tan, Seng-Beng Pang, Yong Kek Liam, Chong Kin COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data |
description |
BackgroundManagement strategies of chronic obstructive pulmonary disease (COPD) need to be tailored to the forced expiratory volume in one second (FEV1), exacerbations, and patient-reported outcomes (PROs) of individual patients. In this study, we analyzed the association and correlation between the FEV1, exacerbations, and PROs of patients with stable COPD.MethodsThis was a post-hoc analysis of pooled data from two cross-sectional studies that were previously conducted in Malaysia from 2017 to 2019, the results of which had been published separately. The parameters measured included post-bronchodilator FEV1 (PB-FEV1), exacerbations, and scores of modified Medical Research Council (mMRC), COPD Assessment Test (CAT), and St George's Respiratory Questionnaire for COPD (SGRQ-c). Descriptive, association, and correlation statistics were used.ResultsThree hundred seventy-four patients were included in the analysis. The PB-FEV1 predicted was < 30% in 85 (22.7%), 30-49% in 142 (38.0%), 50-79% in 111 (29.7%), and >= 80% in 36 (9.6%) patients. Patients with PB-FEV1 < 30% predicted had significantly more COPD exacerbations than those with PB-FEV1 30-49% predicted (p < 0.001), 50-79% predicted (p < 0.001), and >= 80% predicted (p = 0.002). The scores of mMRC, CAT, and SGRQ-c were not significantly higher in patients with more severe airflow limitation based on PB-FEV1 (p = 0.121-0.271). The PB-FEV1 predicted had significant weak negative correlations with exacerbations (r = - 0.182, p < 0.001), mMRC (r = - 0.121, p = 0.020), and SGRQ-c scores (r = - 0.114, p = 0.028). There was a moderate positive correlation between COPD exacerbations and scores of mMRC, CAT, and SGRQ-c (r = 0.407-0.482, all p < 0.001). There were significant strong positive correlations between mMRC score with CAT (r = 0.727) and SGRQ-c scores (r = 0.847), and CAT score with SGRQ-c score (r = 0.851) (all p < 0.001).ConclusionsIn COPD patients, different severity of airflow limitation was not associated with significant differences in the mMRC, CAT, and SGRQ-c scores. Exacerbations were significantly more frequent in patients with very severe airflow limitation only. The correlation between airflow limitation with exacerbations, mMRC, and SGRQ-c was weak. |
format |
Article |
author |
Chai, Chee-Shee Ng, Diana-Leh-Ching Bt Mos, Sumastika Ibrahim, Muhammad Amin B. Tan, Seng-Beng Pang, Yong Kek Liam, Chong Kin |
author_facet |
Chai, Chee-Shee Ng, Diana-Leh-Ching Bt Mos, Sumastika Ibrahim, Muhammad Amin B. Tan, Seng-Beng Pang, Yong Kek Liam, Chong Kin |
author_sort |
Chai, Chee-Shee |
title |
COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data |
title_short |
COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data |
title_full |
COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data |
title_fullStr |
COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data |
title_full_unstemmed |
COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1: A post-hoc analysis of pooled data |
title_sort |
copd exacerbations and patient-reported outcomes according to post-bronchodilator fev1: a post-hoc analysis of pooled data |
publisher |
BMC |
publishDate |
2023 |
url |
http://eprints.um.edu.my/38263/ |
_version_ |
1769842722035728384 |