Benefits and harm of probiotics and synbiotics in adult critically ill patients: A systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

• Main Authors: Lee, Zheng Yii, Lew, Charles Chin Han, Ortiz-Reyes, Alfonso, Patel, Jayshil J., Wong, Yu Jun, Loh, Carolyn Tze Ing, Martindale, Robert G., Heyland, Daren K.
• Format: Article
• Published: Elsevier 2023
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/38345/
• Institution: Universiti Malaya

Background & aims: Several systematic reviews and meta-analyses of randomized controlled trials concluded that probiotics administration in critically ill patients was safe and associated with reduced rates of ventilator-associated pneumonia and diarrhea. However, a recent large multicenter tria...