Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease

Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease

Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental root...

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Main Authors: Perumalsamy, Sangeetha, Zaman Huri, Hasniza, Abdullah, Bashar Mudhaffar, Mazlan, Othman, Wan Ahmad, Wan Azman, Vethakkan, Shireene Ratna D. B.
Format: Article
Published: MDPI 2023
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RC Internal medicine
Online Access:http://eprints.um.edu.my/38539/
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spelling my.um.eprints.385392023-11-30T06:09:53Z http://eprints.um.edu.my/38539/ Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease Perumalsamy, Sangeetha Zaman Huri, Hasniza Abdullah, Bashar Mudhaffar Mazlan, Othman Wan Ahmad, Wan Azman Vethakkan, Shireene Ratna D. B. RC Internal medicine Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2 genes. MDPI 2023-03 Article PeerReviewed Perumalsamy, Sangeetha and Zaman Huri, Hasniza and Abdullah, Bashar Mudhaffar and Mazlan, Othman and Wan Ahmad, Wan Azman and Vethakkan, Shireene Ratna D. B. (2023) Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease. Metabolities, 13 (3). ISSN 2218-1989, DOI https://doi.org/10.3390/metabo13030427 <https://doi.org/10.3390/metabo13030427>. 10.3390/metabo13030427
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RC Internal medicine
spellingShingle RC Internal medicine
Perumalsamy, Sangeetha
Zaman Huri, Hasniza
Abdullah, Bashar Mudhaffar
Mazlan, Othman
Wan Ahmad, Wan Azman
Vethakkan, Shireene Ratna D. B.
Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
description Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2 genes.
format Article
author Perumalsamy, Sangeetha
Zaman Huri, Hasniza
Abdullah, Bashar Mudhaffar
Mazlan, Othman
Wan Ahmad, Wan Azman
Vethakkan, Shireene Ratna D. B.
author_facet Perumalsamy, Sangeetha
Zaman Huri, Hasniza
Abdullah, Bashar Mudhaffar
Mazlan, Othman
Wan Ahmad, Wan Azman
Vethakkan, Shireene Ratna D. B.
author_sort Perumalsamy, Sangeetha
title Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_short Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_full Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_fullStr Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_full_unstemmed Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_sort genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
publisher MDPI
publishDate 2023
url http://eprints.um.edu.my/38539/
_version_ 1784511841781678080

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