Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma

• Main Authors: Jeon, Ah-Jung, Teo, Yue-Yang, Sekar, Karthik, Chong, Shay Lee, Wu, Lingyan, Chew, Sin-Chi, Chen, Jianbin, Kendarsari, Raden Indah, Lai, Hannah, Ling, Wen Huan, Kaya, Neslihan Arife, Lim, Jia Qi, Ramasamy, Adaikalavan, Oguz, Gokce, Chung, Alexander Yaw-Fui, Chan, Chung Yip, Cheow, Peng-Chung, Kam, Juinn Huar, Madhavan, Krishnakumar, Kow, Alfred, Ganpathi, Iyer Shridhar, Lim, Tony Kiat Hon, Leow, Wei-Qiang, Loong, Shihleone, Loh, Tracy Jiezhen, Wan, Wei Keat, Soon, Gwyneth Shook Ting, Pang, Yin Huei, Yoong, Boon Koon, Ong, Diana Bee-Lan, Lim, Jasmine, de Villa, Vanessa H., dela Cruz, Rouchelle D., Chanwat, Rawisak, Thammasiri, Jidapa, Bonney, Glenn K., Goh, Brian K. P., Tucker-Kellogg, Greg, Foo, Roger Sik Yin, Chow, Pierce K. H.
• Format: Article
• Published: BioMed Central 2023
• Subjects: RD Surgery
• Online Access: http://eprints.um.edu.my/38647/
• Institution: Universiti Malaya

BackgroundConventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of patients. This is especially so for highly heterogeneous cancer like Hepatocellular...