Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells

• Main Authors: Leong, Sze Wei, Wang, JingJing, Okuda, Kazuhide Shaun, Su, Qi, Zhang, Yanmin, Abas, Faridah, Chia, Suet Lin, Yusoff, Khatijah
• Format: Article
• Published: Elsevier 2023
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/38863/
• Institution: Universiti Malaya

Unpleasant side effects and resistance development remained the Achilles heel of chemotherapy. Since low tumor-selectivity and monotonous effect of chemotherapy are closely related to such bottleneck, targeting tumor-selective multi-functional anticancer agents may be an ideal strategy in the search...