In-silico approaches for the screening and discovery of broad-spectrum marine natural product antiviral agents against coronaviruses

• Main Authors: Boswell, Zachary, Verga, Jacopo Umberto, Mackle, James, Guerrero-Vazquez, Karen, Thomas, Olivier P., Cray, James, Wolf, Bethany J., Choo, Yeun Mun, Croot, Peter, Hamann, Mark, Hardiman, Gary
• Format: Article
• Published: Dove Medical Press Ltd 2023
• Subjects: QR355 Virology; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/38974/
• Institution: Universiti Malaya

The urgent need for SARS-CoV-2 controls has led to a reassessment of approaches to identify and develop natural product inhibitors of zoonotic, highly virulent, and rapidly emerging viruses. There are yet no clinically approved broad-spectrum antivirals available for beta-coronaviruses. Discovery pi...