Population pharmacokinetics and dosing simulations of intravenous oxycodone for perioperative pain relief in adult surgical patients with obesity

• Main Authors: Chaw, Sook Hui, Lo, Yoke Lin, Yeap, Li Ling, Mohamad Haron, Didi Erwandi, Shariffuddin, Ina Ismiarti
• Format: Article
• Published: Springer France 2023
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/39408/
• Institution: Universiti Malaya

Background and Objective Oxycodone, a semisynthetic thebaine derivative mu-opioid (MOP) receptor agonist, is effective for treating moderate and severe pain in different clinical conditions. The pharmacokinetics of intravenous oxycodone in the obese population has not been studied. This study aims t...