Interleukin-1 alpha and high mobility group box-1 secretion in polyinosinic:polycytidylic-induced colorectal cancer cells occur via RIPK1-dependent mechanism and participate in tumourigenesis

• Main Authors: Cheng, Kim Jun, Mohamed, Elsa Haniffah Mejia, Syafruddin, Saiful Effendi, Ibrahim, Zaridatul Aini
• Format: Article
• Published: Springer 2023
• Subjects: RC Internal medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/39554/
• Institution: Universiti Malaya

Pathogenic infections have significant roles in the pathogenesis of colorectal cancer (CRC). These infections induce the secretion of various damage-associated molecular patterns (DAMPs) including interleukin-1 alpha (IL-1 alpha) and high mobility group box-1 (HMGB1). Despite their implication in CR...