Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications
Biphasic calcium phosphate (BCP) serves as one of the substitutes for bone as it consists of an intimate mixture of beta-tricalcium phosphate (beta-TCP) and hydroxyapatite (HAP) in different ratios. BCP, because of its inbuilt properties such as osteoconductivity, biocompatibility, and biostability...
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my.um.eprints.403012023-11-23T04:29:59Z http://eprints.um.edu.my/40301/ Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications Padmanabhan, Varun Prasath Sivashanmugam, Pugalmani Kulandaivelu, Ravichandran Sagadevan, Suresh Sridevi, Balu Govindasamy, Rajakumar Thiruvengadam, Muthu RM Therapeutics. Pharmacology Biphasic calcium phosphate (BCP) serves as one of the substitutes for bone as it consists of an intimate mixture of beta-tricalcium phosphate (beta-TCP) and hydroxyapatite (HAP) in different ratios. BCP, because of its inbuilt properties such as osteoconductivity, biocompatibility, and biostability in several clinical models serves as a bone substituent for orthopedic applications. Therefore, the present study aimed to assess the effectiveness of silver (Ag) nanoparticles (NPs) combined with BCP composites for the orthopedic sector of bone tissue regeneration and growth. In this regard, we first synthesized Ag-BCP microclusters by the double-emulsion method and then characterized the composite for various physicochemical properties, including the crystallinity and crystal structure, bonding and functionality, porosity, morphology, surface charges, topography, and thermal stability. In addition, the antibacterial activity of Ag-BCP was tested against gram-positive and gram-negative microorganisms such as Staphylococcus aureus, Candida albicans, and Escherichia coli. Finally, the cytocompatibility of Ag-BCP was confirmed against the fibroblast cells in vitro. MDPI 2022-12 Article PeerReviewed Padmanabhan, Varun Prasath and Sivashanmugam, Pugalmani and Kulandaivelu, Ravichandran and Sagadevan, Suresh and Sridevi, Balu and Govindasamy, Rajakumar and Thiruvengadam, Muthu (2022) Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications. Antibiotics-Basel, 11 (12). ISSN 2079-6382, DOI https://doi.org/10.3390/antibiotics11121780 <https://doi.org/10.3390/antibiotics11121780>. 10.3390/antibiotics11121780 |
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RM Therapeutics. Pharmacology Padmanabhan, Varun Prasath Sivashanmugam, Pugalmani Kulandaivelu, Ravichandran Sagadevan, Suresh Sridevi, Balu Govindasamy, Rajakumar Thiruvengadam, Muthu Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications |
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Biphasic calcium phosphate (BCP) serves as one of the substitutes for bone as it consists of an intimate mixture of beta-tricalcium phosphate (beta-TCP) and hydroxyapatite (HAP) in different ratios. BCP, because of its inbuilt properties such as osteoconductivity, biocompatibility, and biostability in several clinical models serves as a bone substituent for orthopedic applications. Therefore, the present study aimed to assess the effectiveness of silver (Ag) nanoparticles (NPs) combined with BCP composites for the orthopedic sector of bone tissue regeneration and growth. In this regard, we first synthesized Ag-BCP microclusters by the double-emulsion method and then characterized the composite for various physicochemical properties, including the crystallinity and crystal structure, bonding and functionality, porosity, morphology, surface charges, topography, and thermal stability. In addition, the antibacterial activity of Ag-BCP was tested against gram-positive and gram-negative microorganisms such as Staphylococcus aureus, Candida albicans, and Escherichia coli. Finally, the cytocompatibility of Ag-BCP was confirmed against the fibroblast cells in vitro. |
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Article |
author |
Padmanabhan, Varun Prasath Sivashanmugam, Pugalmani Kulandaivelu, Ravichandran Sagadevan, Suresh Sridevi, Balu Govindasamy, Rajakumar Thiruvengadam, Muthu |
author_facet |
Padmanabhan, Varun Prasath Sivashanmugam, Pugalmani Kulandaivelu, Ravichandran Sagadevan, Suresh Sridevi, Balu Govindasamy, Rajakumar Thiruvengadam, Muthu |
author_sort |
Padmanabhan, Varun Prasath |
title |
Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications |
title_short |
Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications |
title_full |
Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications |
title_fullStr |
Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications |
title_full_unstemmed |
Biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications |
title_sort |
biosynthesised silver nanoparticles loading onto biphasic calcium phosphate for antibacterial and bone tissue engineering applications |
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MDPI |
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2022 |
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http://eprints.um.edu.my/40301/ |
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1783876699402797056 |