Identification of repurposing therapeutics toward SARS-CoV-2 main protease by virtual screening

• Main Authors: Sanachai, Kamonpan, Somboon, Tuanjai, Wilasluck, Patcharin, Deetanya, Peerapon, Wolschann, Peter, Langer, Thierry, Lee, Vannajan Sanghiran, Wangkanont, Kittikhun, Rungrotmongkol, Thanyada, Hannongbua, Supot
• Format: Article
• Published: Public Library of Science 2022
• Subjects: RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/40442/; https://doi.org/10.1371/journal.pone.0269563
• Institution: Universiti Malaya

SARS-CoV-2 causes the current global pandemic coronavirus disease 2019. Widely-available effective drugs could be a critical factor in halting the pandemic. The main protease (3CL(pro)) plays a vital role in viral replication; therefore, it is of great interest to find inhibitors for this enzyme. We...