The cytokines CXCL10 and CCL2 and the kynurenine metabolite anthranilic acid accurately predict patients at risk of developing dengue with warning signs

• Main Authors: Jusof, Felicita Fedelis, Lim, Chai K., Aziz, Fazidatul Nadhirah, Soe, Hui Jen, Raju, Chandramathi Samudi, Sekaran, Shamala Devi, Guillemin, Gilles J.
• Format: Article
• Published: Oxford University Press (OUP) 2022
• Subjects: QR355 Virology
• Online Access: http://eprints.um.edu.my/40443/; https://doi.org/10.1093/infdis/jiac273
• Institution: Universiti Malaya

Background The resolution or aggravation of dengue infection depends on the patient's immune response during the critical phase. Cytokines released by immune cells increase with the worsening severity of dengue infections. Cytokines activate the kynurenine pathway (KP) and the extent of KP acti...