Isotopic tracer for absolute quantification of metabolites of the pentose phosphate pathway in bacteria

• Main Authors: Mohd Kamal, Khairunnisa, Mahamad Maifiah, Mohd Hafidz, Zhu, Yan, Abdul Rahim, Nusaibah, Hashim, Yumi Zuhanis Has-Yun, Abdullah Sani, Muhamad Shirwan
• Format: Article
• Published: MDPI 2022
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/40749/
• Institution: Universiti Malaya

The pentose phosphate pathway (PPP) plays a key role in many metabolic functions, including the generation of NADPH, biosynthesis of nucleotides, and carbon homeostasis. In particular, the intermediates of PPP have been found to be significantly perturbed in bacterial metabolomic studies. Nonetheles...