Epidemiology (2012-2019) and costs (2009-2019) of dengue in Malaysia: A systematic literature review

• Main Authors: AbuBakar, Sazaly, Puteh, Sharifa Ezat Wan, Kastner, Randee, Oliver, Louisa, Lim, Shi Hao, Hanley, Riona, Gallagher, Elaine
• Format: Article
• Published: Elsevier 2022
• Subjects: RA Public aspects of medicine; General works
• Online Access: http://eprints.um.edu.my/40778/
• Institution: Universiti Malaya

Objectives: A systematic literature review was conducted to assess the epidemiology and economic bur-den of dengue in Malaysia. Methods: Embase, MEDLINE, Evidence-Based Reviews databases, and gray literature sources were searched for English and Malay studies and surveillance reports on the epidemiology (between 2012 and 2019) and costs (between 2009 and 2019) of dengue in Malaysia. Independent screening of ti-tles/abstracts, followed by full texts was performed using prespecified criteria.Results: A total of 198 publications were included (55 peer-reviewed and 143 gray literature). Dengue in-cidence has been increasing in recent years, with 130,101 cases (dengue fever 129,578 cases; dengue hem-orrhagic fever 523 cases) reported in 2019, which is the highest since 2012. All dengue virus serotypes co-circulated between 2004 and 2017, and major outbreaks occurred in a cyclical pattern, often associ-ated with a change in the predominant circulating serotype. Economic impacts are substantial, including the societal impact of lost work (7.2-8.8 days) and school days (3.2-4.1 days) due to dengue.Conclusion: The rising incidence and high cost of dengue, coupled with overlapping diseases, will likely result in further pressures on the healthcare system. To appropriately mitigate and control dengue, it is critical to implement integrated strategies, including vaccination, to reduce the burden of dengue.(c) 2022 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )