Rational attenuation of RNA viruses with zinc finger antiviral protein

• Main Authors: Goncalves-Carneiro, Daniel, Mastrocola, Emily, Lei, Xiao, DaSilva, Justin, Chan, Yoke Fun, Bieniasz, Paul D.
• Format: Article
• Published: Nature Portfolio 2022
• Subjects: QR Microbiology; R Medicine
• Online Access: http://eprints.um.edu.my/41106/
• Institution: Universiti Malaya

Attenuation of a virulent virus is a proven approach for generating vaccines but can be unpredictable. For example, synonymous recoding of viral genomes can attenuate replication but sometimes results in pleiotropic effects that confound rational vaccine design. To enable specific, conditional atten...