Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration

Neutron activation of Sm-152 offers a method of radiolabeling for the in vivo study of oral dose formulations by gamma scintigraphy. Reproducibility measurements are needed to ensure the robustness of clinical studies. 204 enteric-coated guaifenesin core tablets (10 mg of Sm(2)O(3)) were irradiated...

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Main Authors:	Yeong, C.H., Blackshaw, P.E., Ng, K.H., Abdullah, B.J.J., Blaauw, M., Dansereau, R.J., Perkins, A.C.
Format:	Article
Language:	English English
Published:	Elsevier 2011
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/4148/1/sm-153.pdf http://eprints.um.edu.my/4148/2/Production_and_first_use_of_%28SmCl3%29-Sm-153-ion_exchange_resin_capsule_formulation_for_assessing_gastrointestinal_motility.pdf http://eprints.um.edu.my/4148/
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Institution:	Universiti Malaya
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spelling	my.um.eprints.41482024-09-17T07:36:38Z http://eprints.um.edu.my/4148/ Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration Yeong, C.H. Blackshaw, P.E. Ng, K.H. Abdullah, B.J.J. Blaauw, M. Dansereau, R.J. Perkins, A.C. R Medicine Neutron activation of Sm-152 offers a method of radiolabeling for the in vivo study of oral dose formulations by gamma scintigraphy. Reproducibility measurements are needed to ensure the robustness of clinical studies. 204 enteric-coated guaifenesin core tablets (10 mg of Sm(2)O(3)) were irradiated by thermal neutrons to achieve 1 MBq at 48 h. Administered activities were 0.86 +/- 0.03 MBq. Good reproducibility (CV=3.5) was observed over 24 weeks ensuring that volunteer doses were within the dose reference level of 0.8 mSv. Elsevier 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4148/1/sm-153.pdf application/pdf en http://eprints.um.edu.my/4148/2/Production_and_first_use_of_%28SmCl3%29-Sm-153-ion_exchange_resin_capsule_formulation_for_assessing_gastrointestinal_motility.pdf Yeong, C.H. and Blackshaw, P.E. and Ng, K.H. and Abdullah, B.J.J. and Blaauw, M. and Dansereau, R.J. and Perkins, A.C. (2011) Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration. Applied Radiation and Isotopes, 69 (9). pp. 1181-1184. ISSN 0969-8043, DOI https://doi.org/10.1016/j.apradiso.2011.04.017 <https://doi.org/10.1016/j.apradiso.2011.04.017>. 10.1016/j.apradiso.2011.04.017
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
language	English English
topic	R Medicine
spellingShingle	R Medicine Yeong, C.H. Blackshaw, P.E. Ng, K.H. Abdullah, B.J.J. Blaauw, M. Dansereau, R.J. Perkins, A.C. Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration
description	Neutron activation of Sm-152 offers a method of radiolabeling for the in vivo study of oral dose formulations by gamma scintigraphy. Reproducibility measurements are needed to ensure the robustness of clinical studies. 204 enteric-coated guaifenesin core tablets (10 mg of Sm(2)O(3)) were irradiated by thermal neutrons to achieve 1 MBq at 48 h. Administered activities were 0.86 +/- 0.03 MBq. Good reproducibility (CV=3.5) was observed over 24 weeks ensuring that volunteer doses were within the dose reference level of 0.8 mSv.
format	Article
author	Yeong, C.H. Blackshaw, P.E. Ng, K.H. Abdullah, B.J.J. Blaauw, M. Dansereau, R.J. Perkins, A.C.
author_facet	Yeong, C.H. Blackshaw, P.E. Ng, K.H. Abdullah, B.J.J. Blaauw, M. Dansereau, R.J. Perkins, A.C.
author_sort	Yeong, C.H.
title	Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration
title_short	Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration
title_full	Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration
title_fullStr	Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration
title_full_unstemmed	Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration
title_sort	reproducibility of neutron activated sm-153 oral dose formulations intended for human administration
publisher	Elsevier
publishDate	2011
url	http://eprints.um.edu.my/4148/1/sm-153.pdf http://eprints.um.edu.my/4148/2/Production_and_first_use_of_%28SmCl3%29-Sm-153-ion_exchange_resin_capsule_formulation_for_assessing_gastrointestinal_motility.pdf http://eprints.um.edu.my/4148/
_version_	1811682082423832576

Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration

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