Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review
Pemphigus vulgaris is an autoimmune blistering disease with an increased potential for mortality. The epithelium is key in understanding the pathobiology as it is specialized to perform functions like mechanical protection, immunological defense, and proprioception. In order to perform these array o...
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my.um.eprints.415162023-11-06T03:04:56Z http://eprints.um.edu.my/41516/ Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review Hannh, R. Ramani, Pratibha Tilakaratne, Wanninayake Mudiyanselage Sukumaran, Gheena Ramasubramanian, Abilasha Krishnan, Reshma Poothakulath Oral surger Pemphigus vulgaris is an autoimmune blistering disease with an increased potential for mortality. The epithelium is key in understanding the pathobiology as it is specialized to perform functions like mechanical protection, immunological defense, and proprioception. In order to perform these array of functions, epithelial integrity is important. This integrity is maintained by a host of molecules which orchestrate the ability of the keratinocytes to function as a single unit. Desmoglein 3 antibodies formed in genetically susceptible individuals are known to cause the disruption of the intact oral mucosa leading to the formation of blisters in pemphigus vulgaris patients. However, there are underlying complex triggering pathways leading to the clinical disease. The aim of the review is to congregate and critically appraise the various triggering pathways which contribute toward the pathobiology of pemphigus vulgaris. Articles relevant to the pathobiology of pemphigus vulgaris were identified from various search databases till the year 2020. The pathogenesis of pemphigus vulgaris is complex, and it involves an in-depth understanding of the various predisposing factors, provoking factors, and progression mechanisms. Congregation of the various triggering pathways will open our minds to understand pemphigus vulgaris better and in turn develop a reliable treatment in the near future. Blackwell Publishing 2022-10 Article PeerReviewed Hannh, R. and Ramani, Pratibha and Tilakaratne, Wanninayake Mudiyanselage and Sukumaran, Gheena and Ramasubramanian, Abilasha and Krishnan, Reshma Poothakulath (2022) Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review. Oral Diseases, 28 (7). pp. 1760-1769. ISSN 1354-523X, DOI https://doi.org/10.1111/odi.13937 <https://doi.org/10.1111/odi.13937>. 10.1111/odi.13937 |
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Oral surger Hannh, R. Ramani, Pratibha Tilakaratne, Wanninayake Mudiyanselage Sukumaran, Gheena Ramasubramanian, Abilasha Krishnan, Reshma Poothakulath Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review |
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Pemphigus vulgaris is an autoimmune blistering disease with an increased potential for mortality. The epithelium is key in understanding the pathobiology as it is specialized to perform functions like mechanical protection, immunological defense, and proprioception. In order to perform these array of functions, epithelial integrity is important. This integrity is maintained by a host of molecules which orchestrate the ability of the keratinocytes to function as a single unit. Desmoglein 3 antibodies formed in genetically susceptible individuals are known to cause the disruption of the intact oral mucosa leading to the formation of blisters in pemphigus vulgaris patients. However, there are underlying complex triggering pathways leading to the clinical disease. The aim of the review is to congregate and critically appraise the various triggering pathways which contribute toward the pathobiology of pemphigus vulgaris. Articles relevant to the pathobiology of pemphigus vulgaris were identified from various search databases till the year 2020. The pathogenesis of pemphigus vulgaris is complex, and it involves an in-depth understanding of the various predisposing factors, provoking factors, and progression mechanisms. Congregation of the various triggering pathways will open our minds to understand pemphigus vulgaris better and in turn develop a reliable treatment in the near future. |
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Article |
author |
Hannh, R. Ramani, Pratibha Tilakaratne, Wanninayake Mudiyanselage Sukumaran, Gheena Ramasubramanian, Abilasha Krishnan, Reshma Poothakulath |
author_facet |
Hannh, R. Ramani, Pratibha Tilakaratne, Wanninayake Mudiyanselage Sukumaran, Gheena Ramasubramanian, Abilasha Krishnan, Reshma Poothakulath |
author_sort |
Hannh, R. |
title |
Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review |
title_short |
Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review |
title_full |
Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review |
title_fullStr |
Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review |
title_full_unstemmed |
Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review |
title_sort |
critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-a review |
publisher |
Blackwell Publishing |
publishDate |
2022 |
url |
http://eprints.um.edu.my/41516/ |
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1783876720708812800 |