Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice

• Main Authors: Samuvel, Devadoss J., Nguyen, Nga T., Jaeschke, Hartmut, Lemasters, John J., Wang, Xiaojuan, Choo, Yeun Mun, Hamann, Mark T., Zhong, Zhi
• Format: Article
• Published: American Chemical Society 2022
• Subjects: QD Chemistry; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/41621/
• Institution: Universiti Malaya

ABSTRACT: Oxidative stress plays an important role in acetaminophen (APAP)-induced hepatotoxicity. Platanosides (PTSs) isolated from the American sycamore tree (Platanus occidentalis) represent a potential new four-molecule botanical drug class of antibiotics active against drug-resistant infectious...