Cytotoxicity of asymmetric mononuclear silver(I)-N-heterocyclic carbene complexes against human cervical cancer: Synthesis, crystal structure, DFT calculations and effect of substituents

• Main Authors: Zin, Nor Farah Hani Md, Ooi, Shirley Yee Shyen, Khor, Boon-Keat, Chear, Nelson Jeng-Yeou, Tang, Wai Kit, Siu, Chi-Kit, Razali, Mohd. R. ., Haque, Rosenani A., Yam, WanSinn
• Format: Article
• Published: Elsevier Science SA 2022
• Subjects: QD Chemistry; RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/41642/
• Institution: Universiti Malaya

A new series of asymmetrical N,N'-disubstituted benzimidazolium derived N-heterocyclic carbene (NHC) ligands and their mononuclear silver(I)-NHC complexes are reported. The ligands were prepared from N- alkylation of 1-methylbenzimidazole with alkyl bromides (n = 10-18 in even parity), non-fluo...