Small molecules as LIM kinase inhibitors

LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies...

Full description

Saved in:

Bibliographic Details
Main Authors:	Bukhari, Syed N. A., Tandiary, Michael A., Al-Sanea, Mohammad M., Abdelgawad, Mohamed A., Chee, Chin Fei, Hussain, Muhammad A.
Format:	Article
Published:	Bentham Science Publ Ltd 2022
Subjects:	T Technology (General)
Online Access:	http://eprints.um.edu.my/42090/
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Universiti Malaya

id	my.um.eprints.42090
record_format	eprints
spelling	my.um.eprints.420902023-10-18T08:27:49Z http://eprints.um.edu.my/42090/ Small molecules as LIM kinase inhibitors Bukhari, Syed N. A. Tandiary, Michael A. Al-Sanea, Mohammad M. Abdelgawad, Mohamed A. Chee, Chin Fei Hussain, Muhammad A. T Technology (General) LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies have been carried out to discover small organic molecules capable of inhibiting LIM kinase effectively and selectively. In this review, a comprehensive survey of small organic molecules for LIM kinase inhibitors is reported, together with SAR study results, and the synthesis of these inhibitors. Bentham Science Publ Ltd 2022 Article PeerReviewed Bukhari, Syed N. A. and Tandiary, Michael A. and Al-Sanea, Mohammad M. and Abdelgawad, Mohamed A. and Chee, Chin Fei and Hussain, Muhammad A. (2022) Small molecules as LIM kinase inhibitors. Current Medicinal Chemistry, 29 (17). pp. 2995-3027. DOI https://doi.org/10.2174/0929867328666211026120335 <https://doi.org/10.2174/0929867328666211026120335>. 10.2174/0929867328666211026120335
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	T Technology (General)
spellingShingle	T Technology (General) Bukhari, Syed N. A. Tandiary, Michael A. Al-Sanea, Mohammad M. Abdelgawad, Mohamed A. Chee, Chin Fei Hussain, Muhammad A. Small molecules as LIM kinase inhibitors
description	LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies have been carried out to discover small organic molecules capable of inhibiting LIM kinase effectively and selectively. In this review, a comprehensive survey of small organic molecules for LIM kinase inhibitors is reported, together with SAR study results, and the synthesis of these inhibitors.
format	Article
author	Bukhari, Syed N. A. Tandiary, Michael A. Al-Sanea, Mohammad M. Abdelgawad, Mohamed A. Chee, Chin Fei Hussain, Muhammad A.
author_facet	Bukhari, Syed N. A. Tandiary, Michael A. Al-Sanea, Mohammad M. Abdelgawad, Mohamed A. Chee, Chin Fei Hussain, Muhammad A.
author_sort	Bukhari, Syed N. A.
title	Small molecules as LIM kinase inhibitors
title_short	Small molecules as LIM kinase inhibitors
title_full	Small molecules as LIM kinase inhibitors
title_fullStr	Small molecules as LIM kinase inhibitors
title_full_unstemmed	Small molecules as LIM kinase inhibitors
title_sort	small molecules as lim kinase inhibitors
publisher	Bentham Science Publ Ltd
publishDate	2022
url	http://eprints.um.edu.my/42090/
_version_	1781704593732796416

Small molecules as LIM kinase inhibitors

Similar Items