Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination

Bacterial endotoxin contamination in dialysate may pass through haemodialysis mem-brane and cause a silent chronic microinflammation to kidney patients. Dual-layer hollow fibre (DLHF) membranes with dual function, biocompatible adsorptive and antibacterial effects were developed to solve the problem...

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Main Authors: Mansur, Sumarni, Othman, Mohd Hafiz Dzarfan, Zainol Abidin, Muhammad Nidzhom Zainol, Nik Malek, Nik Ahmad Nizam, Ismail, Ahmad Fauzi, Abdul Kadir, Siti Hamimah Sheikh, Goh, Pei Sean, Abdullah, Mohd Sohaimi, Asraf, Muhammad Hariz
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Published: ELSEVIER 2022
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Online Access:http://eprints.um.edu.my/42314/
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spelling my.um.eprints.423142023-10-09T03:43:07Z http://eprints.um.edu.my/42314/ Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination Mansur, Sumarni Othman, Mohd Hafiz Dzarfan Zainol Abidin, Muhammad Nidzhom Zainol Nik Malek, Nik Ahmad Nizam Ismail, Ahmad Fauzi Abdul Kadir, Siti Hamimah Sheikh Goh, Pei Sean Abdullah, Mohd Sohaimi Asraf, Muhammad Hariz Q Science (General) TA Engineering (General). Civil engineering (General) Bacterial endotoxin contamination in dialysate may pass through haemodialysis mem-brane and cause a silent chronic microinflammation to kidney patients. Dual-layer hollow fibre (DLHF) membranes with dual function, biocompatible adsorptive and antibacterial effects were developed to solve the problem of incompatible membrane and endotoxin contamination. All mem-branes were fabricated via the co-extrusion dry-wet phase inversion technique. In this study, silica/ a-mangostin nanoparticle was incorporated into the inner layer of membrane to enhance the bio-compatibility of the membrane while maintaining its adsorption capacity. Activated carbon (AC) was incorporated in the outer layer of membrane for improved antibacterial property. The DLHF membranes were characterised based on its morphology and surface hydrophilicity. The perfor-mance of the DLHF membranes was evaluated in terms of permeability, urea, and creatinine removal capabilities, bovine serum albumin (BSA) rejection and antibacterial properties. The dense and small pore size on the outer layer of AC created a smoother surface for the DLHF membrane. The BSA rejection of the DLHF membranes was enhanced by 6-8% compared to that of unmod-ified single layer hollow fibre membrane. Silica/a-mangostin nanoparticle in the inner layer of mem-brane enhanced the removal of urea and creatinine by chemisorption. Result also showed that the incorporation of AC in the outer layer of DLHF membrane successfully filtered bacteria by bacteria entrapment. DLHF membrane with the combination of silica/a-mangostin nanoparticle in the inner layer and AC in the outer layer possessed the higher bacteria inhibition into blood compartment against Escherichia coli and Staphylococcus aureus, with removal rate of 68% and 75%, respec-tively, and better urea and creatinine removal by 60.57% and 75.18%, respectively, compared to single-layer PSf based membrane. The development of co-adsorptive biocompatible DLHF mem-brane can play an important role in improvement of kidney patient life.(c) 2022 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). ELSEVIER 2022-12 Article PeerReviewed Mansur, Sumarni and Othman, Mohd Hafiz Dzarfan and Zainol Abidin, Muhammad Nidzhom Zainol and Nik Malek, Nik Ahmad Nizam and Ismail, Ahmad Fauzi and Abdul Kadir, Siti Hamimah Sheikh and Goh, Pei Sean and Abdullah, Mohd Sohaimi and Asraf, Muhammad Hariz (2022) Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination. Alexandria Engineering Journal, 61 (12). pp. 10139-10152. ISSN 1110-0168, DOI https://doi.org/10.1016/j.aej.2022.03.043 <https://doi.org/10.1016/j.aej.2022.03.043>. 10.1016/j.aej.2022.03.043
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
TA Engineering (General). Civil engineering (General)
spellingShingle Q Science (General)
TA Engineering (General). Civil engineering (General)
Mansur, Sumarni
Othman, Mohd Hafiz Dzarfan
Zainol Abidin, Muhammad Nidzhom Zainol
Nik Malek, Nik Ahmad Nizam
Ismail, Ahmad Fauzi
Abdul Kadir, Siti Hamimah Sheikh
Goh, Pei Sean
Abdullah, Mohd Sohaimi
Asraf, Muhammad Hariz
Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination
description Bacterial endotoxin contamination in dialysate may pass through haemodialysis mem-brane and cause a silent chronic microinflammation to kidney patients. Dual-layer hollow fibre (DLHF) membranes with dual function, biocompatible adsorptive and antibacterial effects were developed to solve the problem of incompatible membrane and endotoxin contamination. All mem-branes were fabricated via the co-extrusion dry-wet phase inversion technique. In this study, silica/ a-mangostin nanoparticle was incorporated into the inner layer of membrane to enhance the bio-compatibility of the membrane while maintaining its adsorption capacity. Activated carbon (AC) was incorporated in the outer layer of membrane for improved antibacterial property. The DLHF membranes were characterised based on its morphology and surface hydrophilicity. The perfor-mance of the DLHF membranes was evaluated in terms of permeability, urea, and creatinine removal capabilities, bovine serum albumin (BSA) rejection and antibacterial properties. The dense and small pore size on the outer layer of AC created a smoother surface for the DLHF membrane. The BSA rejection of the DLHF membranes was enhanced by 6-8% compared to that of unmod-ified single layer hollow fibre membrane. Silica/a-mangostin nanoparticle in the inner layer of mem-brane enhanced the removal of urea and creatinine by chemisorption. Result also showed that the incorporation of AC in the outer layer of DLHF membrane successfully filtered bacteria by bacteria entrapment. DLHF membrane with the combination of silica/a-mangostin nanoparticle in the inner layer and AC in the outer layer possessed the higher bacteria inhibition into blood compartment against Escherichia coli and Staphylococcus aureus, with removal rate of 68% and 75%, respec-tively, and better urea and creatinine removal by 60.57% and 75.18%, respectively, compared to single-layer PSf based membrane. The development of co-adsorptive biocompatible DLHF mem-brane can play an important role in improvement of kidney patient life.(c) 2022 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
format Article
author Mansur, Sumarni
Othman, Mohd Hafiz Dzarfan
Zainol Abidin, Muhammad Nidzhom Zainol
Nik Malek, Nik Ahmad Nizam
Ismail, Ahmad Fauzi
Abdul Kadir, Siti Hamimah Sheikh
Goh, Pei Sean
Abdullah, Mohd Sohaimi
Asraf, Muhammad Hariz
author_facet Mansur, Sumarni
Othman, Mohd Hafiz Dzarfan
Zainol Abidin, Muhammad Nidzhom Zainol
Nik Malek, Nik Ahmad Nizam
Ismail, Ahmad Fauzi
Abdul Kadir, Siti Hamimah Sheikh
Goh, Pei Sean
Abdullah, Mohd Sohaimi
Asraf, Muhammad Hariz
author_sort Mansur, Sumarni
title Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination
title_short Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination
title_full Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination
title_fullStr Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination
title_full_unstemmed Dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination
title_sort dual-layer hollow fibre haemodialysis membrane for effective uremic toxins removal with minimal blood-bacteria contamination
publisher ELSEVIER
publishDate 2022
url http://eprints.um.edu.my/42314/
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