Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells

• Main Authors: Wathikthinnakon, Methi, Luangwattananun, Piriya, Sawasdee, Nunghathai, Chiawpanit, Chutipa, Lee, Vannajan Sanghiran, Nimmanpipug, Piyarat, Tragoolpua, Yingmanee, Rotarayanont, Siriphorn, Sangsuwannukul, Thanich, Phanthaphol, Nattaporn, Wutti-in, Yupanun, Somboonpatarakun, Chalermchai, Chieochansin, Thaweesak, Junking, Mutita, Sujjitjoon, Jatuporn, Yenchitsomanus, Pa-thai, Panya, Aussara
• Format: Article
• Published: Nature Research 2022
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/42888/
• Institution: Universiti Malaya

Cholangiocarcinoma (CCA) is a lethal cancer with rapid progression and poor survival. Novel and more effective therapies than those currently available are, therefore, urgently needed. Our research group previously reported the combination of gemcitabine and cytotoxic T lymphocytes to be more effect...