Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study

Introduction: Non-adherence to antihypertensive medications is a leading cause of uncontrolled hypertension and its complications. However, data on the factors associated with non-adherence to antihypertensive medications in the communities of Sarawak, Malaysia, are limited. This study aimed to exam...

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Main Authors: Thew, Hui Zhu, Mooi, Ching Siew, Lim, Hooi Min, Mos, Mike Hitler Anak, Tze, Lorna Chin Kin, Low, Kui Feng, Shaari, Nurdarlina, Lin, Jody Yii Sze, Lee, Kai Wei, Ramachandran, Vasudevan
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Published: 2022
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Online Access:http://eprints.um.edu.my/43650/
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spelling my.um.eprints.436502023-10-30T08:23:28Z http://eprints.um.edu.my/43650/ Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study Thew, Hui Zhu Mooi, Ching Siew Lim, Hooi Min Mos, Mike Hitler Anak Tze, Lorna Chin Kin Low, Kui Feng Shaari, Nurdarlina Lin, Jody Yii Sze Lee, Kai Wei Ramachandran, Vasudevan R Medicine (General) Introduction: Non-adherence to antihypertensive medications is a leading cause of uncontrolled hypertension and its complications. However, data on the factors associated with non-adherence to antihypertensive medications in the communities of Sarawak, Malaysia, are limited. This study aimed to examine the prevalence and determinants of medication non-adherence among patients with uncontrolled hypertension. Methods: A cross-sectional study was conducted using the systematic sampling method in four government primary healthcare clinics in Sarawak. A self-administered questionnaire was used to obtain socio-demographic data and evaluate non-adherence. Blood pressure was measured, and relevant clinical variables were collected from medical records. Multivariate logistic regression was used to determine the determinants of medication non-adherence. Results: A total of 488 patients with uncontrolled hypertension were enrolled in this study. The prevalence of medication non-adherence was 39.3. There were four predictors of medication non-adherence among the patients with uncontrolled hypertension: tertiary educational level (odds ratio OR=4.21, 95% confidence interval CI=1.67–10.61, P=0.010), complementary alternative medication (OR=2.03, 95% CI=1.12–3.69, P=0.020), non-usage of calcium channel blockers (OR=1.57, 95% CI=1.02–2.41, P=0.039) and 1 mmHg increase in the systolic blood pressure (OR=1.03, 95% CI=1.00–1.05, P=0.006). Conclusion: Because of the high prevalence of medication non-adherence among patients with uncontrolled hypertension, primary care physicians should be more vigilant in identifying those at risk of being non-adherent. Early intervention should be conducted to address non-adherence for blood pressure control. © 2022, Academy of Family Physicians of Malaysia. All rights reserved. 2022 Article PeerReviewed Thew, Hui Zhu and Mooi, Ching Siew and Lim, Hooi Min and Mos, Mike Hitler Anak and Tze, Lorna Chin Kin and Low, Kui Feng and Shaari, Nurdarlina and Lin, Jody Yii Sze and Lee, Kai Wei and Ramachandran, Vasudevan (2022) Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study. Malaysian Family Physician, 17 (3). 128 -136. ISSN 1985-207X, DOI https://doi.org/10.51866/oa.182 <https://doi.org/10.51866/oa.182>. 10.51866/oa.182
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Thew, Hui Zhu
Mooi, Ching Siew
Lim, Hooi Min
Mos, Mike Hitler Anak
Tze, Lorna Chin Kin
Low, Kui Feng
Shaari, Nurdarlina
Lin, Jody Yii Sze
Lee, Kai Wei
Ramachandran, Vasudevan
Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study
description Introduction: Non-adherence to antihypertensive medications is a leading cause of uncontrolled hypertension and its complications. However, data on the factors associated with non-adherence to antihypertensive medications in the communities of Sarawak, Malaysia, are limited. This study aimed to examine the prevalence and determinants of medication non-adherence among patients with uncontrolled hypertension. Methods: A cross-sectional study was conducted using the systematic sampling method in four government primary healthcare clinics in Sarawak. A self-administered questionnaire was used to obtain socio-demographic data and evaluate non-adherence. Blood pressure was measured, and relevant clinical variables were collected from medical records. Multivariate logistic regression was used to determine the determinants of medication non-adherence. Results: A total of 488 patients with uncontrolled hypertension were enrolled in this study. The prevalence of medication non-adherence was 39.3. There were four predictors of medication non-adherence among the patients with uncontrolled hypertension: tertiary educational level (odds ratio OR=4.21, 95% confidence interval CI=1.67–10.61, P=0.010), complementary alternative medication (OR=2.03, 95% CI=1.12–3.69, P=0.020), non-usage of calcium channel blockers (OR=1.57, 95% CI=1.02–2.41, P=0.039) and 1 mmHg increase in the systolic blood pressure (OR=1.03, 95% CI=1.00–1.05, P=0.006). Conclusion: Because of the high prevalence of medication non-adherence among patients with uncontrolled hypertension, primary care physicians should be more vigilant in identifying those at risk of being non-adherent. Early intervention should be conducted to address non-adherence for blood pressure control. © 2022, Academy of Family Physicians of Malaysia. All rights reserved.
format Article
author Thew, Hui Zhu
Mooi, Ching Siew
Lim, Hooi Min
Mos, Mike Hitler Anak
Tze, Lorna Chin Kin
Low, Kui Feng
Shaari, Nurdarlina
Lin, Jody Yii Sze
Lee, Kai Wei
Ramachandran, Vasudevan
author_facet Thew, Hui Zhu
Mooi, Ching Siew
Lim, Hooi Min
Mos, Mike Hitler Anak
Tze, Lorna Chin Kin
Low, Kui Feng
Shaari, Nurdarlina
Lin, Jody Yii Sze
Lee, Kai Wei
Ramachandran, Vasudevan
author_sort Thew, Hui Zhu
title Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study
title_short Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study
title_full Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study
title_fullStr Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study
title_full_unstemmed Prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in Sarawak, Malaysia: A cross-sectional study
title_sort prevalence and determinants of medications non-adherence among patients with uncontrolled hypertension in primary care setting in sarawak, malaysia: a cross-sectional study
publishDate 2022
url http://eprints.um.edu.my/43650/
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