Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes

• Main Authors: Aldoghachi, Asraa Faris, Yanagisawa, Daijiro, Arrozi, Aslina Pahrudin, Bakar, Zulzikry Hafiz Abu, Taguchi, Hiroyasu, Ishigaki, Shinsuke, Morino, Katsutaro, Tooyama, Ikuo
• Format: Article
• Published: ACADEMIC PRESS INC ELSEVIER SCIENCE 2024
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/44220/; https://doi.org/10.1016/j.bbrc.2023.149392
• Institution: Universiti Malaya

Thioredoxin interacting protein (TXNIP) has emerged as a significant regulator of 8-cell mass and loss, rendering it an attractive target for treating diabetes. We previously showed that Shiga-Y6, a fluorinated curcumin derivative, inhibited TXNIP mRNA and protein expression in vitro, raising the qu...