Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceuti...
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2024
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my.um.eprints.449612024-04-29T01:33:03Z http://eprints.um.edu.my/44961/ Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond Ravindar, Lekkala Hasbullah, Siti Aishah Rakesh, K.P. Raheem, Saki Agustar, Hani Kartini Ismail, Norzila Lau, Yee Ling Hassan, Nurul Izzaty QD Chemistry R Medicine RS Pharmacy and materia medica Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceutical importance of aminoquinoline derivatives, herein, we review the recent developments (since 2019) in various biological activities of the 4-aminoquinoline scaffold hybridized with diverse heterocyclic moieties such as quinoline, pyridine, pyrimidine, triazine, dioxine, piperazine, pyrazoline, piperidine, imidazole, indole, oxadiazole, carbazole, dioxole, thiazole, benzothiazole, pyrazole, phthalimide, adamantane, benzochromene, and pyridinone. Moreover, by gaining knowledge about SARs, structural insights, and molecular targets, this review may help medicinal chemists design cost-effective, selective, safe, and more potent 4-aminoquinoline hybrids for diverse biological activities. © 2023 Elsevier Masson SAS Elsevier Masson s.r.l. 2024 Article PeerReviewed Ravindar, Lekkala and Hasbullah, Siti Aishah and Rakesh, K.P. and Raheem, Saki and Agustar, Hani Kartini and Ismail, Norzila and Lau, Yee Ling and Hassan, Nurul Izzaty (2024) Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond. European Journal of Medicinal Chemistry, 264. ISSN 0223-5234, DOI https://doi.org/10.1016/j.ejmech.2023.116043 <https://doi.org/10.1016/j.ejmech.2023.116043>. 10.1016/j.ejmech.2023.116043 |
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QD Chemistry R Medicine RS Pharmacy and materia medica Ravindar, Lekkala Hasbullah, Siti Aishah Rakesh, K.P. Raheem, Saki Agustar, Hani Kartini Ismail, Norzila Lau, Yee Ling Hassan, Nurul Izzaty Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond |
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Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceutical importance of aminoquinoline derivatives, herein, we review the recent developments (since 2019) in various biological activities of the 4-aminoquinoline scaffold hybridized with diverse heterocyclic moieties such as quinoline, pyridine, pyrimidine, triazine, dioxine, piperazine, pyrazoline, piperidine, imidazole, indole, oxadiazole, carbazole, dioxole, thiazole, benzothiazole, pyrazole, phthalimide, adamantane, benzochromene, and pyridinone. Moreover, by gaining knowledge about SARs, structural insights, and molecular targets, this review may help medicinal chemists design cost-effective, selective, safe, and more potent 4-aminoquinoline hybrids for diverse biological activities. © 2023 Elsevier Masson SAS |
format |
Article |
author |
Ravindar, Lekkala Hasbullah, Siti Aishah Rakesh, K.P. Raheem, Saki Agustar, Hani Kartini Ismail, Norzila Lau, Yee Ling Hassan, Nurul Izzaty |
author_facet |
Ravindar, Lekkala Hasbullah, Siti Aishah Rakesh, K.P. Raheem, Saki Agustar, Hani Kartini Ismail, Norzila Lau, Yee Ling Hassan, Nurul Izzaty |
author_sort |
Ravindar, Lekkala |
title |
Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond |
title_short |
Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond |
title_full |
Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond |
title_fullStr |
Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond |
title_full_unstemmed |
Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond |
title_sort |
exploring diverse frontiers: advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond |
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Elsevier Masson s.r.l. |
publishDate |
2024 |
url |
http://eprints.um.edu.my/44961/ |
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1797906861799768064 |