Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond

Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceuti...

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Main Authors: Ravindar, Lekkala, Hasbullah, Siti Aishah, Rakesh, K.P., Raheem, Saki, Agustar, Hani Kartini, Ismail, Norzila, Lau, Yee Ling, Hassan, Nurul Izzaty
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Published: Elsevier Masson s.r.l. 2024
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Online Access:http://eprints.um.edu.my/44961/
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spelling my.um.eprints.449612024-04-29T01:33:03Z http://eprints.um.edu.my/44961/ Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond Ravindar, Lekkala Hasbullah, Siti Aishah Rakesh, K.P. Raheem, Saki Agustar, Hani Kartini Ismail, Norzila Lau, Yee Ling Hassan, Nurul Izzaty QD Chemistry R Medicine RS Pharmacy and materia medica Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceutical importance of aminoquinoline derivatives, herein, we review the recent developments (since 2019) in various biological activities of the 4-aminoquinoline scaffold hybridized with diverse heterocyclic moieties such as quinoline, pyridine, pyrimidine, triazine, dioxine, piperazine, pyrazoline, piperidine, imidazole, indole, oxadiazole, carbazole, dioxole, thiazole, benzothiazole, pyrazole, phthalimide, adamantane, benzochromene, and pyridinone. Moreover, by gaining knowledge about SARs, structural insights, and molecular targets, this review may help medicinal chemists design cost-effective, selective, safe, and more potent 4-aminoquinoline hybrids for diverse biological activities. © 2023 Elsevier Masson SAS Elsevier Masson s.r.l. 2024 Article PeerReviewed Ravindar, Lekkala and Hasbullah, Siti Aishah and Rakesh, K.P. and Raheem, Saki and Agustar, Hani Kartini and Ismail, Norzila and Lau, Yee Ling and Hassan, Nurul Izzaty (2024) Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond. European Journal of Medicinal Chemistry, 264. ISSN 0223-5234, DOI https://doi.org/10.1016/j.ejmech.2023.116043 <https://doi.org/10.1016/j.ejmech.2023.116043>. 10.1016/j.ejmech.2023.116043
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
R Medicine
RS Pharmacy and materia medica
spellingShingle QD Chemistry
R Medicine
RS Pharmacy and materia medica
Ravindar, Lekkala
Hasbullah, Siti Aishah
Rakesh, K.P.
Raheem, Saki
Agustar, Hani Kartini
Ismail, Norzila
Lau, Yee Ling
Hassan, Nurul Izzaty
Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
description Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceutical importance of aminoquinoline derivatives, herein, we review the recent developments (since 2019) in various biological activities of the 4-aminoquinoline scaffold hybridized with diverse heterocyclic moieties such as quinoline, pyridine, pyrimidine, triazine, dioxine, piperazine, pyrazoline, piperidine, imidazole, indole, oxadiazole, carbazole, dioxole, thiazole, benzothiazole, pyrazole, phthalimide, adamantane, benzochromene, and pyridinone. Moreover, by gaining knowledge about SARs, structural insights, and molecular targets, this review may help medicinal chemists design cost-effective, selective, safe, and more potent 4-aminoquinoline hybrids for diverse biological activities. © 2023 Elsevier Masson SAS
format Article
author Ravindar, Lekkala
Hasbullah, Siti Aishah
Rakesh, K.P.
Raheem, Saki
Agustar, Hani Kartini
Ismail, Norzila
Lau, Yee Ling
Hassan, Nurul Izzaty
author_facet Ravindar, Lekkala
Hasbullah, Siti Aishah
Rakesh, K.P.
Raheem, Saki
Agustar, Hani Kartini
Ismail, Norzila
Lau, Yee Ling
Hassan, Nurul Izzaty
author_sort Ravindar, Lekkala
title Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
title_short Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
title_full Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
title_fullStr Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
title_full_unstemmed Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
title_sort exploring diverse frontiers: advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
publisher Elsevier Masson s.r.l.
publishDate 2024
url http://eprints.um.edu.my/44961/
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