CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country

Cytomegalovirus (CMV) infection is one of the common complications which can lead to significant morbidity and mortality in patients after allogeneic hematopoietic stem cell transplantation (HSCT). As the seroprevalence of CMV infection in Malaysia is high, this study aims to determine the prevalenc...

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Main Authors: Sulaiman, Noor Yuhyi, Anuar, Nur Adila, Arshad, Normala, Cheong, Chin Sum, Liong, Chee Chiat, Khairullah, Shasha, Chin, Edmund Fui Min, Bee, Ping Chong, Sam, I-Ching, Iyadorai, Thevambiga, Gan, Gin Gin
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Published: Springer India 2024
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Online Access:http://eprints.um.edu.my/45029/
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spelling my.um.eprints.450292024-03-25T07:00:16Z http://eprints.um.edu.my/45029/ CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country Sulaiman, Noor Yuhyi Anuar, Nur Adila Arshad, Normala Cheong, Chin Sum Liong, Chee Chiat Khairullah, Shasha Chin, Edmund Fui Min Bee, Ping Chong Sam, I-Ching Iyadorai, Thevambiga Gan, Gin Gin QR Microbiology R Medicine (General) Cytomegalovirus (CMV) infection is one of the common complications which can lead to significant morbidity and mortality in patients after allogeneic hematopoietic stem cell transplantation (HSCT). As the seroprevalence of CMV infection in Malaysia is high, this study aims to determine the prevalence of CMV infection in patients post HSCT and to evaluate the associated risk factors. Patients who underwent allogeneic HSCT in adult ward from 2008 to 2020 at a tertiary teaching hospital in Kuala Lumpur, Malaysia were studied retrospectively. They were followed up for a minimum of 100 days post-HSCT to determine the incidence of CMV infection. CMV infection was defined according to CMV Drug Development Forum 2014. Risk factors such as type of transplant, serostatus of donor and patients, age, gender, race, presence of graft versus host disease (GVHD) and underlying disease were included for analysis. A total of 112 patients were included. Forty (35.7) patients had CMV infection with median of onset recorded as 40 days (range 13–95 days). Only haplo-identical HSCT and presence of GVHD were identified as significant risk factors. Patients who had CMV infection had a lower median survival time although this was not statistically significant. The CMV infection rate was comparable with previous reports in Asia and as expected, higher than the western countries. Therefore, vigilant monitoring of CMV infection should be implemented especially in patients who had haplo-identical HSCT and acute GVHD. © 2023, The Author(s), under exclusive licence to Indian Society of Hematology and Blood Transfusion. Springer India 2024 Article PeerReviewed Sulaiman, Noor Yuhyi and Anuar, Nur Adila and Arshad, Normala and Cheong, Chin Sum and Liong, Chee Chiat and Khairullah, Shasha and Chin, Edmund Fui Min and Bee, Ping Chong and Sam, I-Ching and Iyadorai, Thevambiga and Gan, Gin Gin (2024) CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country. Indian Journal of Hematology and Blood Transfusion, 40 (1). 97 – 102. ISSN 0971-4502, DOI https://doi.org/10.1007/s12288-023-01655-0 <https://doi.org/10.1007/s12288-023-01655-0>. 10.1007/s12288-023-01655-0
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QR Microbiology
R Medicine (General)
spellingShingle QR Microbiology
R Medicine (General)
Sulaiman, Noor Yuhyi
Anuar, Nur Adila
Arshad, Normala
Cheong, Chin Sum
Liong, Chee Chiat
Khairullah, Shasha
Chin, Edmund Fui Min
Bee, Ping Chong
Sam, I-Ching
Iyadorai, Thevambiga
Gan, Gin Gin
CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country
description Cytomegalovirus (CMV) infection is one of the common complications which can lead to significant morbidity and mortality in patients after allogeneic hematopoietic stem cell transplantation (HSCT). As the seroprevalence of CMV infection in Malaysia is high, this study aims to determine the prevalence of CMV infection in patients post HSCT and to evaluate the associated risk factors. Patients who underwent allogeneic HSCT in adult ward from 2008 to 2020 at a tertiary teaching hospital in Kuala Lumpur, Malaysia were studied retrospectively. They were followed up for a minimum of 100 days post-HSCT to determine the incidence of CMV infection. CMV infection was defined according to CMV Drug Development Forum 2014. Risk factors such as type of transplant, serostatus of donor and patients, age, gender, race, presence of graft versus host disease (GVHD) and underlying disease were included for analysis. A total of 112 patients were included. Forty (35.7) patients had CMV infection with median of onset recorded as 40 days (range 13–95 days). Only haplo-identical HSCT and presence of GVHD were identified as significant risk factors. Patients who had CMV infection had a lower median survival time although this was not statistically significant. The CMV infection rate was comparable with previous reports in Asia and as expected, higher than the western countries. Therefore, vigilant monitoring of CMV infection should be implemented especially in patients who had haplo-identical HSCT and acute GVHD. © 2023, The Author(s), under exclusive licence to Indian Society of Hematology and Blood Transfusion.
format Article
author Sulaiman, Noor Yuhyi
Anuar, Nur Adila
Arshad, Normala
Cheong, Chin Sum
Liong, Chee Chiat
Khairullah, Shasha
Chin, Edmund Fui Min
Bee, Ping Chong
Sam, I-Ching
Iyadorai, Thevambiga
Gan, Gin Gin
author_facet Sulaiman, Noor Yuhyi
Anuar, Nur Adila
Arshad, Normala
Cheong, Chin Sum
Liong, Chee Chiat
Khairullah, Shasha
Chin, Edmund Fui Min
Bee, Ping Chong
Sam, I-Ching
Iyadorai, Thevambiga
Gan, Gin Gin
author_sort Sulaiman, Noor Yuhyi
title CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country
title_short CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country
title_full CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country
title_fullStr CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country
title_full_unstemmed CMV infection post allogeneic hematopoietic stem cell transplantation in a resource limited country
title_sort cmv infection post allogeneic hematopoietic stem cell transplantation in a resource limited country
publisher Springer India
publishDate 2024
url http://eprints.um.edu.my/45029/
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