Discovery of indoleninyl-pyrazolo[3,4-b]pyridines as potent chemotherapeutic agents against colorectal cancer cells

Discovery of indoleninyl-pyrazolo[3,4-b]pyridines as potent chemotherapeutic agents against colorectal cancer cells

A new series of indolenines decorated with pyrazolo3,4-b]pyridines were designed and synthesized in up to 96% yield from the acid-catalyzed cyclocondensation of 1,3-dialdehydes with 3-aminopyrazoles. X-ray crystallography on a representative derivative, 5n, revealed two close to planar conformations...

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Bibliographic Details
Main Authors: Basir, Nur Husnaini, Ramle, Abdul Qaiyum, Ng, Min Phin, Tan, Chun Hoe, Tiekink, Edward R.T., Sim, Kae Shin, Basirun, Wan Jefrey, Khairuddean, Melati
Format: Article
Published: Elsevier 2024
Subjects:
QD Chemistry
QH Natural history
Online Access:http://eprints.um.edu.my/45465/
https://doi.org/10.1016/j.bioorg.2024.107256
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Institution: Universiti Malaya

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http://eprints.um.edu.my/45465/
https://doi.org/10.1016/j.bioorg.2024.107256

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