Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension

• المؤلفون الرئيسيون: Al-Daghestani, Hiba, Qaisar, Rizwan, Al Kawas, Sausan, Ghani, Nurhafizah, Rani, K. G. Aghila, Azeem, Muhammad, Hasnan, Hijaz Kamal, Kassim, Nur Karyatee, Samsudin, A. R.
• التنسيق: مقال
• منشور في: Nature Research 2024
• الموضوعات: Q Science (General)
• الوصول للمادة أونلاين: http://eprints.um.edu.my/45552/; https://doi.org/10.1038/s41598-024-54944-7

Hindlimb suspension (HLS) mice exhibit osteoporosis of the hindlimb bones and may be an excellent model to test pharmacological interventions. We investigated the effects of inhibiting endoplasmic reticulum (ER) stress with 4-phenyl butyrate (4-PBA) on the morphology, physicochemical properties, and...