Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1

Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nu...

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Main Authors:	Aghafar, M.Z.K.A, Witt, C., Kamarulzaman, A., Ismail, R., Lederman, M.M., Rodriguez, B., Senitzer, D., Lee, S., Price, P.
Format:	Article
Published:	2012
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/4583/
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Institution:	Universiti Malaya

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spelling	my.um.eprints.45832013-01-25T01:50:18Z http://eprints.um.edu.my/4583/ Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1 Aghafar, M.Z.K.A Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M.M. Rodriguez, B. Senitzer, D. Lee, S. Price, P. R Medicine Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort. 2012 Article PeerReviewed Aghafar, M.Z.K.A and Witt, C. and Kamarulzaman, A. and Ismail, R. and Lederman, M.M. and Rodriguez, B. and Senitzer, D. and Lee, S. and Price, P. (2012) Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1. Tissue Antigens, 79 (5). pp. 367-371. ISSN 0001-2815
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Aghafar, M.Z.K.A Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M.M. Rodriguez, B. Senitzer, D. Lee, S. Price, P. Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
description	Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort.
format	Article
author	Aghafar, M.Z.K.A Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M.M. Rodriguez, B. Senitzer, D. Lee, S. Price, P.
author_facet	Aghafar, M.Z.K.A Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M.M. Rodriguez, B. Senitzer, D. Lee, S. Price, P.
author_sort	Aghafar, M.Z.K.A
title	Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
title_short	Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
title_full	Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
title_fullStr	Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
title_full_unstemmed	Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
title_sort	genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to hiv-1
publishDate	2012
url	http://eprints.um.edu.my/4583/
_version_	1643687367511375872

Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1

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